Mitogenicity of peroxisome proliferators in monolayers of adult rat hepatocytes

Dose-response curves with known peroxisome proliferators (or related compounds) were obtained. The mitogenic potency of peroxisome proliferators could not be predicted from their effects on the peroxisomal compartment. Ranking of the substances according to their ability to induce replicative DNA sy...

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Published inFood and Chemical Toxicology [FOOD CHEM. TOXICOL.]. Vol. 24, no. 6-7. 1986 Vol. 24; no. 6; p. 709
Main Authors Bieri, F., Bentley, P., Waechter, F., Stäubli, W.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Elsevier Ltd 1986
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Summary:Dose-response curves with known peroxisome proliferators (or related compounds) were obtained. The mitogenic potency of peroxisome proliferators could not be predicted from their effects on the peroxisomal compartment. Ranking of the substances according to their ability to induce replicative DNA synthesis in cultured hepatocytes was more in agreement with their hepatomegalic potency (as judged from a compilation of published in vivo studies) than was their ranking as peroxisome proliferators.
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ISSN:0278-6915
1873-6351
DOI:10.1016/0278-6915(86)90168-7