Current Developments of Pyrrolo[2,3-d]pyrimidines with Anticancer Potential (A Review)

Anticancer chemotherapeutics are effective weapons for cancer therapy, but the continuous emergency of multidrug-resistant cancer and the side effects of current available anticancer chemotherapeutics are the major obstacles in the control and eradication of cancers. Pyrrolo[2,3- d ]pyrimidines coul...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 93; no. 10; pp. 2645 - 2662
Main Authors Tan, Z.-Y., Deng, J., Ye, Q.-X., Zhang, Z.-F., Luo, T.-Y.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2023
Springer
Springer Nature B.V
Subjects
Anticancer properties
Antimitotic agents
Antineoplastic agents
Cancer
Care and treatment
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug resistance in microorganisms
Health aspects
Pyrimidines
Side effects
hybrid
pyrimidine
pyrrolo[2,3
anticancer
mechanisms of action
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Summary:Anticancer chemotherapeutics are effective weapons for cancer therapy, but the continuous emergency of multidrug-resistant cancer and the side effects of current available anticancer chemotherapeutics are the major obstacles in the control and eradication of cancers. Pyrrolo[2,3- d ]pyrimidines could inhibit signal transduction cascades affecting cell proliferation, migration, and angiogenesis, representing privileged scaffolds for the discovery of novel anticancer candidates. This review highlighted the recent developments of pyrrolo[2,3- d ]pyrimidines with anticancer potential and discussed mechanisms of action, covering papers published from 2018 to present, to facilitate further rational design of more effective candidates.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223100195