Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones

• Published in: European journal of medicinal chemistry Vol. 44; no. 4; pp. 1623 - 1629
• Main Authors: Gligorijevic, Nevenka, Todorovic, Tamara, Radulovic, Sinisa, Sladic, Dusan, Filipovic, Nenad, Godevac, Dejan, Jeremic, Dejan, Andelkovic, Katarina
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier 01.04.2009
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cadmium - chemistry; Cell Cycle - drug effects; Cell Line, Tumor; Chemistry, Medicinal; General aspects; Humans; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Nickel - chemistry; Organoplatinum Compounds - chemistry; Organoplatinum Compounds - pharmacology; Palladium - chemistry; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Platinum - chemistry; Science & Technology; Spectrophotometry, Infrared; Zinc - chemistry; Heterocyclic compounds; Selenosemicarbazone; SEMICARBAZONES; CRYSTAL-STRUCTURE; THIOSEMICARBAZONES; Antitumor activity; NMR spectroscopy; Complexes; Antineoplastic agent; Divalent metal Complexes; Cadmium II Complexes; Flow cytometry; Zinc II Complexes; Cytotoxicity; NMR spectrometry; Uterine cervix; Cell cycle; Mammary gland; Chemical synthesis; Tumor cell; Platinum II Complexes; Human; Palladium II Complexes; Melanoma; Organic ligand; Quinoline derivatives; Transition metal Complexes; Epithelium; In vitro; Hela cell line; Biological activity; Cell line; Platinoid Complexes; Nickel II Complexes
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2008.07.033

New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated. (c) 2008 Elsevier Masson SAS. All rights reserved.