Visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN to 2-aminobenzothiazoles without photocatalyst

• Published in: Chinese chemical letters Vol. 31; no. 7; pp. 1895 - 1898
• Main Authors: He, Wei-Bao, Gao, Lan-Qing, Chen, Xin-Jie, Wu, Zhi-Lin, Huang, Ying, Cao, Zhong, Xu, Xin-Hua, He, Wei-Min
• Format: Journal Article
• Language: English
• Published: NEW YORK Elsevier B.V 01.07.2020; Elsevier; Department of Chemistry, Hunan University, Changsha 410082, China%School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China%School of Chemistry and Chemical Engineering,University of South China%Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology,Changsha 410114, China
• Subjects: 2-Aminobenzothiazoles; Air; Cascade reaction; Chemistry; Chemistry, Multidisciplinary; Photocatalysis; Photocatalyst-free; Physical Sciences; Science & Technology; Cascade reaction; 2-Aminobenzothiazoles; Photocatalyst-free; Air; Photocatalysis; OXIDATION; DESIGN; CATALYST-FREE; HYDROXYLATION; EFFICIENT SYNTHESIS; REDUCTIVE MINISCI REACTION; METAL; QUINOXALIN-2(1H)-ONES; DERIVATIVES; MOLECULAR-OXYGEN
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2020.02.011

A simple and practical method for the synthesis of 2-aminobenzothiazoles through visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN with ambient air as an oxidant in eco-friendly bis(methoxypropy) ether at ambient temperature was developed. [Display omitted] By using ambient air as the oxidant and malic acid as the promoter, a practical method for the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of aromatic amines and KSCN in eco-friendly bis(methoxypropy)ether under metal-, hazardous additive-, photocatalyst-free conditions was established.