Age at Graft Loss after Pediatric Kidney Transplantation: Exploring the High-Risk Age Window

• Published in: Clinical journal of the American Society of Nephrology Vol. 8; no. 6; pp. 1019 - 1026
• Main Authors: Van Arendonk, Kyle J, James, Nathan T, Boyarsky, Brian J, Garonzik-Wang, Jacqueline M, Orandi, Babak J, Magee, John C, Smith, Jodi M, Colombani, Paul M, Segev, Dorry L
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.06.2013
• Subjects: Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Graft Survival; Humans; Kidney Transplantation - adverse effects; Male; Models, Statistical; Multivariate Analysis; Original; Risk Factors; Time Factors; Treatment Outcome; Young Adult
• ISSN: 1555-9041; 1555-905X
• DOI: 10.2215/CJN.10311012

The risk of graft loss after pediatric kidney transplantation increases during late adolescence and early adulthood, but the extent to which this phenomenon affects all recipients is unknown. This study explored interactions between recipient factors and this high-risk age window, searching for a recipient phenotype that may be less susceptible during this detrimental age interval. With use of Scientific Registry of Transplant Recipients data from 1987 to 2010, risk of graft loss across recipient age was quantified using a multivariable piecewise-constant hazard rate model with time-varying coefficients for recipient risk factors. Among 16,266 recipients, graft loss during ages ≥17 and <24 years was greater than that for both 3-17 years (adjusted hazard ratio [aHR], 1.61; P<0.001) and ≥24 years (aHR, 1.28; P<0.001). This finding was consistent across age at transplantation, sex, race, cause of renal disease, insurance type, pretransplant dialysis history, previous transplant, peak panel-reactive antibody (PRA), and type of induction immunosuppression. The high-risk window was seen in both living-donor and deceased-donor transplant recipients, at all levels of HLA mismatch, regardless of centers' pediatric transplant volume, and consistently over time. The relationship between graft loss risk and donor type, PRA, transplant history, insurance type, and cause of renal disease was diminished upon entry into the high-risk window. No recipient subgroups are exempt from the dramatic increase in graft loss during late adolescence and early adulthood, a high-risk window that modifies the relationship between typical recipient risk factors and graft loss.