Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions
An efficient route for the synthesis of 5-(arylpropenylidine)-2,4,6-pyrimidinetrione 3 from an appropriate α,β-unsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically importa...
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Published in | Chinese chemical letters Vol. 18; no. 12; pp. 1431 - 1435 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.12.2007
Department of Chemistry, Kakatiya University, Warangal 506 009, India |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient route for the synthesis of 5-(arylpropenylidine)-2,4,6-pyrimidinetrione
3 from an appropriate α,β-unsaturated aromatic aldehydes
1 and barbituric acid
2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically important compounds
3 was obtained in good to excellent yields (86–98%) in a very short reaction time (30–80
s). |
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ISSN: | 1001-8417 1878-5964 |
DOI: | 10.1016/j.cclet.2007.10.016 |