Knoevenagel condensation of α,β-unsaturated aromatic aldehydes with barbituric acid under non-catalytic and solvent-free conditions

An efficient route for the synthesis of 5-(arylpropenylidine)-2,4,6-pyrimidinetrione 3 from an appropriate α,β-unsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically importa...

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Bibliographic Details
Published inChinese chemical letters Vol. 18; no. 12; pp. 1431 - 1435
Main Authors Reddy, Cherkupally Sanjeeva, Nagaraj, Adki
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2007
Department of Chemistry, Kakatiya University, Warangal 506 009, India
Subjects
5-(Arylpropenylidine)-2,4,6-pyrimidinetrione
Barbituric acid
Knoevenagel condensation
Barbituric acid
5-(Arylpropenylidine)-2,4,6-pyrimidinetrione
Knoevenagel condensation
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Summary:An efficient route for the synthesis of 5-(arylpropenylidine)-2,4,6-pyrimidinetrione 3 from an appropriate α,β-unsaturated aromatic aldehydes 1 and barbituric acid 2 under both non-catalytic and solvent-free microwave irradiation conditions was described. In this way, a range of biologically important compounds 3 was obtained in good to excellent yields (86–98%) in a very short reaction time (30–80 s).
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2007.10.016