Targeting of a Thermosensitive Nanogel Copolymerized With Macromonomer for Cell Uptake and Drug Controlled Release

In this study, N-isopropylacrylamide (NIPAAm), propyl acrylic acid (PAAC), and poly(N-isopropylacrylamide-co-undecylenic acid) acrylamide were introduced to synthesize PNIPAAm-based nanogels (NG). The morphology of NG particles was characterized via transmission electron microscopy (TEM). The nanoge...

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Published inInternational journal of polymeric materials Vol. 64; no. 8; pp. 400 - 405
Main Authors Liu, Zhenzhen, Zhang, Xinling, Rao, Minyu, Lu, Li, Liang, Peiqing, Wu, Jianxiang, Quan, Changyun, Zhang, Chao
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 12.09.2015
Taylor & Francis Ltd
Subjects
Biosynthesis
Cell targeting
Copolymers
drug-loading capacity
macromonomer
Morphology
Peptides
Pharmacology
Temperature effects
thermosensitive nanogels
Transmission electron microscopy
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Summary:In this study, N-isopropylacrylamide (NIPAAm), propyl acrylic acid (PAAC), and poly(N-isopropylacrylamide-co-undecylenic acid) acrylamide were introduced to synthesize PNIPAAm-based nanogels (NG). The morphology of NG particles was characterized via transmission electron microscopy (TEM). The nanogels exhibited a lower critical solution temperature (LCST) of 34°C and a temperature-induced drug release in vitro. After conjugation of arginine-glycine-aspartic acid (RGD)-containing peptide (GRGDS), the cellular uptake of doxorubicin (Dox)-loaded nanogel by HeLa cells had been greatly enhanced. The Dox molecules in endocytosed nanogels could be released efficiently at 37°C and subsequently kill tumor cells, suggesting that the nanogel has great potential for targeting delivery.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2014.958827