Gallium-67-labelled red blood cells as a blood-pool marker for dual-isotope imaging

Red blood cells were labelled with 67Ga oxine prepared from 67Ga citrate, a routinely available and relatively inexpensive radiopharmaceutical which is suitable for dual-isotope imaging with 99mTc. Labelling efficiency was 88 ± 1%, 24-h in vitro stability was 93 ± 5% in saline at room temperature an...

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Bibliographic Details
Published inInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Vol. 19; no. 1; pp. 79 - 81
Main Authors Ballinger, James R., Boxen, I
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1992
Pergamon
Subjects
Biological and medical sciences
Erythrocytes - metabolism
Gallium Radioisotopes
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Oxyquinoline - chemistry
Pyridines - chemistry
Radionuclide investigations
Thiones
Tropolone - blood
Tropolone - metabolism
Radionuclide study
Radiolabelling
Red blood cell
Double labelling
Technique
Radiopharmaceuticals
Blood
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Summary:Red blood cells were labelled with 67Ga oxine prepared from 67Ga citrate, a routinely available and relatively inexpensive radiopharmaceutical which is suitable for dual-isotope imaging with 99mTc. Labelling efficiency was 88 ± 1%, 24-h in vitro stability was 93 ± 5% in saline at room temperature and 68 ± 4% in whole blood at 37 °C, and the method could be performed within 20–30 min.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0883-2897
DOI:10.1016/0883-2897(92)90188-5