Oxime derivatives of sordaricin as potent antifungal agents

Oxime derivatives of the sordarin aglycone have been identified as potent antifungal agents. The in vitro spectrum of activity includes coverage against Candida albicans and Candida glabrata with MICs as low as 0.06 microg/mL. The antifungal activity was established to be exquisitely sensitive to th...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 12; no. 6; pp. 943 - 946
Main Authors SERRANO-WU, Michael H, LAURENT, Denis R. St, MAZZUCCO, Charles E, STICKLE, Terry M, BARRETT, John F, VYAS, Dolatrai M, BALASUBRAMANIAN, Balu N
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 25.03.2002
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - pharmacology
Biological and medical sciences
Candida - drug effects
Diterpenes
Hydrophobic and Hydrophilic Interactions
Medical sciences
Microbial Sensitivity Tests
Oximes - chemical synthesis
Oximes - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
Candida albicans
Terpenoid
Aldehydoacid
Isoxazole derivatives
Aglycone
Candida glabrata
Tetracyclic compound
In vitro
Fungi
Antifungal agent
Structure activity relation
Carboxylic acid
Diterpene
Aldoxime
Fungi Imperfecti
Chemical synthesis
Thallophyta
Oxygen nitrogen heterocycle
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Summary:Oxime derivatives of the sordarin aglycone have been identified as potent antifungal agents. The in vitro spectrum of activity includes coverage against Candida albicans and Candida glabrata with MICs as low as 0.06 microg/mL. The antifungal activity was established to be exquisitely sensitive to the spatial orientation of the lipophilic side chains.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00054-9