A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 123; pp. 330 - 341
• Main Authors: Le, Jing-Qing, Yang, Fang, Song, Xun-Huan, Feng, Ke-Ke, Tong, Ling-Wu, Yin, Meng-Die, Zhang, Wen-Zhong, Lin, Ying-Qi, Wu, Hui, Shao, Jing-Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.07.2023; 한국공업화학회
• Subjects: Chemo-photo therapy; Hemoglobin; Hepatocellular carcinoma; Hypoxia; Self-assembly; 화학공학; Hemoglobin; Hypoxia; Hepatocellular carcinoma; Self-assembly; Chemo-photo therapy

Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually...