A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma

Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 123; pp. 330 - 341
Main Authors Le, Jing-Qing, Yang, Fang, Song, Xun-Huan, Feng, Ke-Ke, Tong, Ling-Wu, Yin, Meng-Die, Zhang, Wen-Zhong, Lin, Ying-Qi, Wu, Hui, Shao, Jing-Wei
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.07.2023
한국공업화학회
Subjects
Chemo-photo therapy
Hemoglobin
Hepatocellular carcinoma
Hypoxia
Self-assembly
화학공학
Hemoglobin
Hypoxia
Hepatocellular carcinoma
Self-assembly
Chemo-photo therapy
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Summary:Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually becomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystem containing hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolic acid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellular carcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to the sensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyanine green. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and ameliorate the tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drug delivery system was expected to effectively reduce the resistance of traditional treatment methods against tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinoma treatment.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2023.03.050