A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma

Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 123; pp. 330 - 341
Main Authors Le, Jing-Qing, Yang, Fang, Song, Xun-Huan, Feng, Ke-Ke, Tong, Ling-Wu, Yin, Meng-Die, Zhang, Wen-Zhong, Lin, Ying-Qi, Wu, Hui, Shao, Jing-Wei
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.07.2023
한국공업화학회
Subjects
Chemo-photo therapy
Hemoglobin
Hepatocellular carcinoma
Hypoxia
Self-assembly
화학공학
Hemoglobin
Hypoxia
Hepatocellular carcinoma
Self-assembly
Chemo-photo therapy
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Abstract Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually becomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystem containing hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolic acid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellular carcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to the sensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyanine green. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and ameliorate the tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drug delivery system was expected to effectively reduce the resistance of traditional treatment methods against tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinoma treatment.
AbstractList Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesis and metastasis, but also is responsible for the development of treatment resistance, which gradually becomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystem containing hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolic acid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellular carcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to the sensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyanine green. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and ameliorate the tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drug delivery system was expected to effectively reduce the resistance of traditional treatment methods against tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinoma treatment.
Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, whichprovides a suitable environment for cancer growth. The hypoxia not only elevates tumor angiogenesisand metastasis, but also is responsible for the development of treatment resistance, which graduallybecomes a significant impediment for cancer therapy. Therefore, we developed a biomimetic nanosystemcontaining hemoglobin extracted from red blood cells, chemotherapy drug sorafenib, sensitizer ursolicacid and photosensitizer indocyanine green for enhanced chemo-photo combination therapy of hepatocellularcarcinoma, which could not only enhance the chemotherapy effect of sorafenib bowing to thesensitizing effect of ursolic acid, but also achieved synergetic phototherapy in virtue of indocyaninegreen. Besides, the nanoparticles could effectively delivery exogenous oxygen to tumor site and amelioratethe tumor hypoxic environment with the assistance of hemoglobin. The dual-sensitization drugdelivery system was expected to effectively reduce the resistance of traditional treatment methodsagainst tumor hypoxia, providing a novel prospect for the synergistic hepatocellular carcinomatreatment. KCI Citation Count: 0
Author Feng, Ke-Ke
Zhang, Wen-Zhong
Lin, Ying-Qi
Le, Jing-Qing
Yin, Meng-Die
Shao, Jing-Wei
Wu, Hui
Yang, Fang
Song, Xun-Huan
Tong, Ling-Wu
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Cites_doi 10.1002/adfm.201703197
10.1002/adhm.201800525
10.1016/j.ajps.2021.12.003
10.1021/acsami.0c17660
10.1016/j.actbio.2020.03.034
10.1021/acsami.6b11373
10.1021/acsami.7b14755
10.1038/s41572-020-00240-3
10.1002/anie.201903417
10.1039/C9TB00687G
10.1016/j.actbio.2021.02.030
10.7150/thno.55441
10.1016/j.ijpharm.2019.118663
10.1002/smll.202200116
10.1002/adma.201802228
10.1016/j.jconrel.2017.05.011
10.1038/s41467-019-12412-1
10.1007/s12274-020-3265-z
10.1016/j.biomaterials.2020.120537
10.1021/acsami.0c11636
10.1021/acsnano.0c06415
10.1039/D0BM00678E
10.1002/adma.202106390
10.1016/j.actbio.2018.01.028
10.1002/adma.201204683
10.1016/j.biomaterials.2017.07.030
10.1021/acs.nanolett.1c01220
10.1016/j.msec.2022.112691
10.7150/thno.48448
10.1039/D2BM00803C
10.1002/advs.202103836
10.1038/s41467-020-16439-7
10.1021/acsami.6b05817
10.1016/j.tcb.2014.11.006
10.1039/D0TB01967D
10.1021/acsami.5b05347
10.7150/thno.54822
10.7150/thno.37586
10.1093/annonc/mdz103
10.1039/D1TB00554E
10.1038/nnano.2014.208
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Keywords Hemoglobin
Hypoxia
Hepatocellular carcinoma
Self-assembly
Chemo-photo therapy
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References Gao, Huang, Liu, Kwong, Yue, Wan, Lee, Wang (b0055) 2020; 11
Li, Yu, Liu, Luo, Law, Zheng, Huang, Li (b0080) 2022; 182
Jansman, Coll-Satue, Liu, Kempen, Andresen, Thulstrup, Hosta-Rigau (b0175) 2022; 134
Hao, Chen, Wu (b0065) 2021; 14
Chung, Tan, Gao, Yongvongsoontorn, Kim, Lee, Choi, Yano, Zhuo, Kurisawa, Ying (b0200) 2014; 9
Wang, Luo, Wu, Tang, Liu, Liu, Shen, Ren, Wu (b0165) 2020; 14
Wang, Guo, Wang, Jiang, Liu, Yuan, Yan, Hu, Wu (b0125) 2021; 269
Saleem, Wang, Chen (b0095) 2018; 7
Tian, Luo, Liu, Zheng, Chen, Ma, Liang, Han, Lu, Cai (b0160) 2017; 27
Godet, Shin, Ju, Ye, Wang, Gilkes (b0105) 2019; 10
Zhong, Li, Hua, Qi, Xie, Qiao, Zhou (b0140) 2021; 11
Yang, Zhao, Fang, Jiang, Yuan, Shao (b0085) 2019; 570
Klemm, Joyce (b0100) 2015; 25
Wu, Shen, Jiang, Zhang, Zhang, Zou, Lin, Li, Shao (b0025) 2022; 10
Guo, Jiang, Shen, Zheng, Fan, Zhao, Shao (b0045) 2017; 9
Peng, Xiao, Chen, Gao (b0090) 2022; 9
Liu, Hu, Zhang, Wang, Li (b0050) 2019; 58
Yuan, Liang, Zhou, Xiao, Liu, Yang, Ma, Cheng, Lin (b0170) 2021; 21
Muthuraj, Mukherjee, Patra, Iyer (b0190) 2016; 8
Liu, Ai, Liu, Deng, He, Lu (b0185) 2013; 25
Zhao, Chen, Pan, Li, Xue, Okeke, Wang, Li, Peng, Wang, Ma, Liang (b0215) 2015; 7
Zhang, Luo, Zou, Wu, Jiang, Le, Zhao, Chen, Shao (b0030) 2020; 12
Liu, Pan, Cao, Xia, Liu, Niu, Alfranca, Sun, Ma, de la Fuente, Song, Ni, Cui (b0135) 2019; 9
Zhao, Zheng, Fan, Shen, Jiang, Guo, Shao (b0040) 2018; 70
Sun, Kwong, Gao, Wei, Yue, Zhang, Ye, Wang (b0060) 2020; 10
Fu, Li, Yang, Jiang, Wang, Fu, Zhu, Hao (b0115) 2021; 268
Song, Wang, Hou, Kala, Qiu, Wong, Cao, Sun (b0150) 2020; 108
Gulzar, He, Gulzar, Kuang, Zhang, Gai, Yang, Wang (b0155) 2021; 9
Zhao, Li, Zheng, Jiang, Fan, Shao (b0075) 2017; 143
Wang, Jiang, Li, Luo, Lin, Hu, Xu, Zhu, Fan (b0110) 2020; 8
Llovet, Kelley, Villanueva, Singal, Pikarsky, Roayaie, Lencioni, Koike, Zucman-Rossi, Finn (b0005) 2021; 7
Zhang, Wu, Zou, Jiang, Zhao, Luo, Liao, Shao (b0020) 2020; 393
Yuan, Deng, Qin, Mu, Chen, Liu (b0130) 2021; 125
Zhang, Li, Ma, Zhang, Guan, Zhang, Zhang, Jing, Yue (b0180) 2016; 8
Kong, Ye, Miao, Liu, Huang, Xiong, Wen, Zhang (b0070) 2021; 11
Chen, Chen, Yang, Xu, Xu, Liang, Han, Liu (b0145) 2019; 31
Wu, Li, Zhong, Shi, Cheng, He, Li, Zou, Fu, Chen, Zhang, Gao (b0015) 2022; 17
Hu, Luo, Qu, Liao, Huang, Chen, Cai, Bao, Chen, Li, Cui (b0205) 2020; 12
Han, Tu, Qiao, Sun, Li, Sun, Wu (b0120) 2021; 9
Lin, Li, Guo, Zou, Wu, Liao, Zhang, Le, Zhao, Shao (b0035) 2019; 7
Li, Liu, Ma, Lin, Lin, Su, Chen, Ye, Chen, Zhu, Hou (b0195) 2017; 258
Xu, He, Dai, Yu, Wang, Li, Jiang, Ke, Su, Peng, Guo, Chen, Chen, Peng, Kuang (b0010) 2019; 30
Zhao, Xu, Feng, Ren, Bao, Zhao, Tao, Zhao, Yang (b0210) 2022; 34
Zhu, Jin, Liu, Dai, Li, Zheng, Wang, Shen, Yu, Wu, Wu, Zhong, Cheng, Liu (b0220) 2022; 18
Yang (10.1016/j.jiec.2023.03.050_b0085) 2019; 570
Song (10.1016/j.jiec.2023.03.050_b0150) 2020; 108
Hao (10.1016/j.jiec.2023.03.050_b0065) 2021; 14
Jansman (10.1016/j.jiec.2023.03.050_b0175) 2022; 134
Chen (10.1016/j.jiec.2023.03.050_b0145) 2019; 31
Godet (10.1016/j.jiec.2023.03.050_b0105) 2019; 10
Chung (10.1016/j.jiec.2023.03.050_b0200) 2014; 9
Liu (10.1016/j.jiec.2023.03.050_b0185) 2013; 25
Sun (10.1016/j.jiec.2023.03.050_b0060) 2020; 10
Wang (10.1016/j.jiec.2023.03.050_b0110) 2020; 8
Muthuraj (10.1016/j.jiec.2023.03.050_b0190) 2016; 8
Gulzar (10.1016/j.jiec.2023.03.050_b0155) 2021; 9
Zhao (10.1016/j.jiec.2023.03.050_b0040) 2018; 70
Zhang (10.1016/j.jiec.2023.03.050_b0180) 2016; 8
Zhao (10.1016/j.jiec.2023.03.050_b0075) 2017; 143
Lin (10.1016/j.jiec.2023.03.050_b0035) 2019; 7
Fu (10.1016/j.jiec.2023.03.050_b0115) 2021; 268
Xu (10.1016/j.jiec.2023.03.050_b0010) 2019; 30
Zhu (10.1016/j.jiec.2023.03.050_b0220) 2022; 18
Kong (10.1016/j.jiec.2023.03.050_b0070) 2021; 11
Zhang (10.1016/j.jiec.2023.03.050_b0030) 2020; 12
Zhong (10.1016/j.jiec.2023.03.050_b0140) 2021; 11
Wang (10.1016/j.jiec.2023.03.050_b0165) 2020; 14
Han (10.1016/j.jiec.2023.03.050_b0120) 2021; 9
Yuan (10.1016/j.jiec.2023.03.050_b0170) 2021; 21
Wu (10.1016/j.jiec.2023.03.050_b0015) 2022; 17
Li (10.1016/j.jiec.2023.03.050_b0195) 2017; 258
Guo (10.1016/j.jiec.2023.03.050_b0045) 2017; 9
Zhao (10.1016/j.jiec.2023.03.050_b0215) 2015; 7
Gao (10.1016/j.jiec.2023.03.050_b0055) 2020; 11
Llovet (10.1016/j.jiec.2023.03.050_b0005) 2021; 7
Li (10.1016/j.jiec.2023.03.050_b0080) 2022; 182
Saleem (10.1016/j.jiec.2023.03.050_b0095) 2018; 7
Yuan (10.1016/j.jiec.2023.03.050_b0130) 2021; 125
Wang (10.1016/j.jiec.2023.03.050_b0125) 2021; 269
Peng (10.1016/j.jiec.2023.03.050_b0090) 2022; 9
Hu (10.1016/j.jiec.2023.03.050_b0205) 2020; 12
Liu (10.1016/j.jiec.2023.03.050_b0050) 2019; 58
Tian (10.1016/j.jiec.2023.03.050_b0160) 2017; 27
Klemm (10.1016/j.jiec.2023.03.050_b0100) 2015; 25
Liu (10.1016/j.jiec.2023.03.050_b0135) 2019; 9
Zhang (10.1016/j.jiec.2023.03.050_b0020) 2020; 393
Wu (10.1016/j.jiec.2023.03.050_b0025) 2022; 10
Zhao (10.1016/j.jiec.2023.03.050_b0210) 2022; 34
References_xml – volume: 58
  start-page: 8804
  year: 2019
  end-page: 8808
  ident: b0050
  publication-title: Angewandte Chemie International Edition
– volume: 9
  start-page: 43508
  year: 2017
  end-page: 43519
  ident: b0045
  publication-title: ACS Appl. Mater. Interfaces
– volume: 9
  start-page: 6751
  year: 2021
  end-page: 6769
  ident: b0120
  publication-title: J. Mater. Chem. B
– volume: 9
  start-page: e2103836
  year: 2022
  ident: b0090
  publication-title: Adv. Sci.
– volume: 8
  start-page: 21465
  year: 2016
  end-page: 21471
  ident: b0180
  publication-title: ACS Appl. Mater. Interfaces
– volume: 11
  start-page: 5464
  year: 2021
  end-page: 5490
  ident: b0070
  publication-title: Theranostics
– volume: 9
  start-page: 6867
  year: 2019
  end-page: 6884
  ident: b0135
  publication-title: Theranostics
– volume: 10
  start-page: 10106
  year: 2020
  end-page: 10119
  ident: b0060
  publication-title: Theranostics
– volume: 269
  year: 2021
  ident: b0125
  publication-title: Biomaterials
– volume: 31
  start-page: e1802228
  year: 2019
  ident: b0145
  publication-title: Adv. Mater.
– volume: 27
  start-page: 1703197
  year: 2017
  ident: b0160
  publication-title: Adv. Funct. Mater.
– volume: 9
  start-page: 907
  year: 2014
  end-page: 912
  ident: b0200
  publication-title: Nat. Nanotechnol.
– volume: 18
  start-page: e2200116
  year: 2022
  ident: b0220
  publication-title: Small (Weinheim an der Bergstrasse, Germany)
– volume: 8
  start-page: 4595
  year: 2020
  end-page: 4602
  ident: b0110
  publication-title: Biomater. Sci.
– volume: 8
  start-page: 32220
  year: 2016
  end-page: 32229
  ident: b0190
  publication-title: ACS Appl. Mater. Interfaces
– volume: 25
  start-page: 198
  year: 2015
  end-page: 213
  ident: b0100
  publication-title: Trends Cell Biol.
– volume: 268
  year: 2021
  ident: b0115
  publication-title: Biomaterials
– volume: 134
  year: 2022
  ident: b0175
  publication-title: Biomater. Adv.
– volume: 108
  start-page: 313
  year: 2020
  end-page: 325
  ident: b0150
  publication-title: Acta biomaterialia
– volume: 70
  start-page: 197
  year: 2018
  end-page: 210
  ident: b0040
  publication-title: Acta biomaterialia
– volume: 10
  start-page: 4862
  year: 2019
  ident: b0105
  publication-title: Nat. Commun.
– volume: 7
  start-page: 6
  year: 2021
  ident: b0005
  publication-title: Nat. Rev. Dis. Primers
– volume: 14
  start-page: 2491
  year: 2021
  end-page: 2511
  ident: b0065
  publication-title: Nano Res.
– volume: 125
  start-page: 1
  year: 2021
  end-page: 28
  ident: b0130
  publication-title: Acta biomaterialia
– volume: 12
  start-page: 42511
  year: 2020
  end-page: 42520
  ident: b0205
  publication-title: ACS Appl. Mater. Interfaces
– volume: 182
  year: 2022
  ident: b0080
  publication-title: Pharmacol. Res.
– volume: 393
  year: 2020
  ident: b0020
  publication-title: Chem. Eng. J.
– volume: 21
  start-page: 6042
  year: 2021
  end-page: 6050
  ident: b0170
  publication-title: Nano Lett.
– volume: 9
  start-page: 131
  year: 2021
  end-page: 146
  ident: b0155
  publication-title: J. Mater. Chem. B
– volume: 12
  start-page: 57362
  year: 2020
  end-page: 57372
  ident: b0030
  publication-title: ACS Appl. Mater. Interfaces
– volume: 7
  start-page: 6914
  year: 2019
  end-page: 6923
  ident: b0035
  publication-title: J. Mater. Chem. B
– volume: 570
  year: 2019
  ident: b0085
  publication-title: Int. J. Pharm.
– volume: 17
  start-page: 206
  year: 2022
  end-page: 218
  ident: b0015
  publication-title: Asian J. Pharm. Sci.
– volume: 7
  start-page: e1800525
  year: 2018
  ident: b0095
  publication-title: Adv. Healthc. Mater.
– volume: 10
  start-page: 6267
  year: 2022
  end-page: 6281
  ident: b0025
  publication-title: Biomater. Sci.
– volume: 11
  start-page: 3580
  year: 2021
  end-page: 3594
  ident: b0140
  publication-title: Theranostics
– volume: 25
  start-page: 1353
  year: 2013
  end-page: 1359
  ident: b0185
  publication-title: Adv. Mater.
– volume: 143
  start-page: 1
  year: 2017
  end-page: 16
  ident: b0075
  publication-title: Biomaterials
– volume: 34
  start-page: 2106390
  year: 2022
  ident: b0210
  publication-title: Adv. Mater.
– volume: 30
  start-page: 990
  year: 2019
  end-page: 997
  ident: b0010
  publication-title: Ann. Oncol.: Official J. Eur. Soc. Med. Oncol.
– volume: 258
  start-page: 95
  year: 2017
  end-page: 107
  ident: b0195
  publication-title: J. Control. Release
– volume: 7
  start-page: 19295
  year: 2015
  end-page: 19305
  ident: b0215
  publication-title: ACS Appl. Mater. Interfaces
– volume: 14
  start-page: 17046
  year: 2020
  end-page: 17062
  ident: b0165
  publication-title: ACS nano
– volume: 11
  start-page: 2622
  year: 2020
  ident: b0055
  publication-title: Nat. Commun.
– volume: 27
  start-page: 1703197
  year: 2017
  ident: 10.1016/j.jiec.2023.03.050_b0160
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201703197
– volume: 182
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0080
  publication-title: Pharmacol. Res.
– volume: 7
  start-page: e1800525
  year: 2018
  ident: 10.1016/j.jiec.2023.03.050_b0095
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201800525
– volume: 17
  start-page: 206
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0015
  publication-title: Asian J. Pharm. Sci.
  doi: 10.1016/j.ajps.2021.12.003
– volume: 12
  start-page: 57362
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0030
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.0c17660
– volume: 108
  start-page: 313
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0150
  publication-title: Acta biomaterialia
  doi: 10.1016/j.actbio.2020.03.034
– volume: 8
  start-page: 32220
  year: 2016
  ident: 10.1016/j.jiec.2023.03.050_b0190
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b11373
– volume: 9
  start-page: 43508
  year: 2017
  ident: 10.1016/j.jiec.2023.03.050_b0045
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b14755
– volume: 7
  start-page: 6
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0005
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/s41572-020-00240-3
– volume: 58
  start-page: 8804
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0050
  publication-title: Angewandte Chemie International Edition
  doi: 10.1002/anie.201903417
– volume: 7
  start-page: 6914
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0035
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C9TB00687G
– volume: 125
  start-page: 1
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0130
  publication-title: Acta biomaterialia
  doi: 10.1016/j.actbio.2021.02.030
– volume: 11
  start-page: 3580
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0140
  publication-title: Theranostics
  doi: 10.7150/thno.55441
– volume: 570
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0085
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2019.118663
– volume: 18
  start-page: e2200116
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0220
  publication-title: Small (Weinheim an der Bergstrasse, Germany)
  doi: 10.1002/smll.202200116
– volume: 31
  start-page: e1802228
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0145
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201802228
– volume: 258
  start-page: 95
  year: 2017
  ident: 10.1016/j.jiec.2023.03.050_b0195
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.05.011
– volume: 10
  start-page: 4862
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0105
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12412-1
– volume: 14
  start-page: 2491
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0065
  publication-title: Nano Res.
  doi: 10.1007/s12274-020-3265-z
– volume: 393
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0020
  publication-title: Chem. Eng. J.
– volume: 268
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0115
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120537
– volume: 12
  start-page: 42511
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0205
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.0c11636
– volume: 269
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0125
  publication-title: Biomaterials
– volume: 14
  start-page: 17046
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0165
  publication-title: ACS nano
  doi: 10.1021/acsnano.0c06415
– volume: 8
  start-page: 4595
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0110
  publication-title: Biomater. Sci.
  doi: 10.1039/D0BM00678E
– volume: 34
  start-page: 2106390
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0210
  publication-title: Adv. Mater.
  doi: 10.1002/adma.202106390
– volume: 70
  start-page: 197
  year: 2018
  ident: 10.1016/j.jiec.2023.03.050_b0040
  publication-title: Acta biomaterialia
  doi: 10.1016/j.actbio.2018.01.028
– volume: 25
  start-page: 1353
  year: 2013
  ident: 10.1016/j.jiec.2023.03.050_b0185
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201204683
– volume: 143
  start-page: 1
  year: 2017
  ident: 10.1016/j.jiec.2023.03.050_b0075
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2017.07.030
– volume: 21
  start-page: 6042
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0170
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.1c01220
– volume: 134
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0175
  publication-title: Biomater. Adv.
  doi: 10.1016/j.msec.2022.112691
– volume: 10
  start-page: 10106
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0060
  publication-title: Theranostics
  doi: 10.7150/thno.48448
– volume: 10
  start-page: 6267
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0025
  publication-title: Biomater. Sci.
  doi: 10.1039/D2BM00803C
– volume: 9
  start-page: e2103836
  year: 2022
  ident: 10.1016/j.jiec.2023.03.050_b0090
  publication-title: Adv. Sci.
  doi: 10.1002/advs.202103836
– volume: 11
  start-page: 2622
  year: 2020
  ident: 10.1016/j.jiec.2023.03.050_b0055
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16439-7
– volume: 8
  start-page: 21465
  year: 2016
  ident: 10.1016/j.jiec.2023.03.050_b0180
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b05817
– volume: 25
  start-page: 198
  year: 2015
  ident: 10.1016/j.jiec.2023.03.050_b0100
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2014.11.006
– volume: 9
  start-page: 131
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0155
  publication-title: J. Mater. Chem. B
  doi: 10.1039/D0TB01967D
– volume: 7
  start-page: 19295
  year: 2015
  ident: 10.1016/j.jiec.2023.03.050_b0215
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.5b05347
– volume: 11
  start-page: 5464
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0070
  publication-title: Theranostics
  doi: 10.7150/thno.54822
– volume: 9
  start-page: 6867
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0135
  publication-title: Theranostics
  doi: 10.7150/thno.37586
– volume: 30
  start-page: 990
  year: 2019
  ident: 10.1016/j.jiec.2023.03.050_b0010
  publication-title: Ann. Oncol.: Official J. Eur. Soc. Med. Oncol.
  doi: 10.1093/annonc/mdz103
– volume: 9
  start-page: 6751
  year: 2021
  ident: 10.1016/j.jiec.2023.03.050_b0120
  publication-title: J. Mater. Chem. B
  doi: 10.1039/D1TB00554E
– volume: 9
  start-page: 907
  year: 2014
  ident: 10.1016/j.jiec.2023.03.050_b0200
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2014.208
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Snippet Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, which provides a suitable environment for cancer growth. The...
Tumor microenvironment is characterized by low pH, high reactive oxygen species and hypoxia, whichprovides a suitable environment for cancer growth. The...
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SubjectTerms Chemo-photo therapy
Hemoglobin
Hepatocellular carcinoma
Hypoxia
Self-assembly
화학공학
Title A hemoglobin-based oxygen-carrying biomimetic nanosystem for enhanced chemo-phototherapy and hypoxia alleviation of hepatocellular carcinoma
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