Synthesis of New Imidazolidin-2-ones Based on the Reaction of 1-(2,2-Dimethoxyethyl)urea with C-Nucleophiles

The acid-catalyzed reaction of 1-(2,2-dimethoxyethyl)ureas with aromatic and heterocyclic nucleophiles leads to the formation of new imidazolidin-2-ones. The proposed method makes it quite easy to introduce the desired pharmacophore group into position 4 of the imidazolidine ring.

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 93; no. 6; pp. 1322 - 1326
Main Authors Smolobochkin, A. V., Kuznetsova, E. A., Gazizov, A. S., Burilov, A. R., Pudovik, M. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.06.2023
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Mezlocillin
Nucleophiles
Physical Sciences
Science & Technology
Urea
Ureas
imidazolidin-2-one
1-(2,2-dimethoxyethyl)urea
acetals
nucleophiles
INHIBITION
HETEROCYCLES
C-nucleophiles
DIVERSITY
1-
2-dimethoxyethyl)urea
UREA
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Summary:The acid-catalyzed reaction of 1-(2,2-dimethoxyethyl)ureas with aromatic and heterocyclic nucleophiles leads to the formation of new imidazolidin-2-ones. The proposed method makes it quite easy to introduce the desired pharmacophore group into position 4 of the imidazolidine ring.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223060026