Glucocorticoid-induced osteoporosis: Insights for the clinician

Glucocorticoids cause significant bone loss, predominantly affecting trabecular bone, with consequent fragility fractures. The risk of fractures is related to the dose and duration of glucocorticoid use, but an increased risk may be observed even at low doses and even in the first month of treatment...

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Bibliographic Details
Published inCleveland Clinic journal of medicine Vol. 87; no. 7; pp. 417 - 426
Main Authors Hayat, Shakaib, Magrey, Marina N
Format Journal Article
LanguageEnglish
Published United States 01.07.2020
Subjects
Adult
Bone Density - drug effects
Cancellous Bone - drug effects
Drug Administration Schedule
Female
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Humans
Male
Middle Aged
Osteoporosis - chemically induced
Osteoporotic Fractures - chemically induced
Prednisone - administration & dosage
Prednisone - adverse effects
Risk Factors
Time Factors
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Summary:Glucocorticoids cause significant bone loss, predominantly affecting trabecular bone, with consequent fragility fractures. The risk of fractures is related to the dose and duration of glucocorticoid use, but an increased risk may be observed even at low doses and even in the first month of treatment. Steps to prevent or treat osteoporosis should be considered in all patients who take the equivalent of prednisone at a dose of 2.5 mg or more per day for 3 or more months.
ISSN:0891-1150
1939-2869
DOI:10.3949/ccjm.87a.19039