Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines: Construction of 1,2-disubstituted isoquinolinones
In this study, a method was developed to form C(sp3)–C(sp2) bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions. The multi-component tandem reaction was used to construct new C–N, C=O and C–C bonds in one pot via seque...
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Published in | Chinese chemical letters Vol. 33; no. 11; pp. 4874 - 4877 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
01.11.2022
School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,China%Affiliated Hospital of Guilin Medical University,Guilin 541001,China |
Subjects | |
Online Access | Get full text |
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Summary: | In this study, a method was developed to form C(sp3)–C(sp2) bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions. The multi-component tandem reaction was used to construct new C–N, C=O and C–C bonds in one pot via sequential functionalization of the N1, C3 and C1 positions of 3-haloisoquinoline. This method can be used to efficiently access 1,2-disubstituted isoquinolinones by the three-component reaction of 3-halogen isoquinoline, alkyl halide, and 2-methylquinoline.
Herein, a method was developed to form C(sp3)-C(sp2) bonds through a copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ activated 3-haloisoquinoline under mild conditions. The multi-component tandem reaction constructed new C-N, C=O, and C-C bonds in one pot through the sequential functionalization of the N1, C3, and C1 positions of 3-haloisoquinoline. This method can efficiently construct 1,2-disubstituted isoquinolinones through the three-component reaction of 3-halogen isoquinoline, alkyl halide, and 2-methylquinoline. [Display omitted] |
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ISSN: | 1001-8417 1878-5964 |
DOI: | 10.1016/j.cclet.2022.02.032 |