The effect of age on release of norepinephrine by tyramine from rat heart

• Published in: Mechanisms of ageing and development Vol. 36; no. 3; pp. 281 - 285
• Main Authors: Kreider, Margaret S., Goldberg, Paula Bursztyn, Roberts, Jay
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 14.11.1986; Elsevier Science
• Subjects: Aging; Aging - physiology; Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Heart; Heart Rate - drug effects; In Vitro Techniques; Male; Myocardium - metabolism; Neuroeffector Junction - drug effects; Neuroeffector Junction - metabolism; Norepinephrine - metabolism; Norepinephrine release; Rat heart; Rats; Rats, Inbred F344; Tyramine; Tyramine - pharmacology; Vertebrates: cardiovascular system; Tyramine; Aging; Norepinephrine release; Rat heart; Heart; Vertebrata; Senescence; Mammalia; Rat; Secretion; Rodentia; Norepinephrine; Circulatory system; Catecholamine; Age
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/0047-6374(86)90093-X

The effect of age on the capacity of tyramine to promote the release of norepinephrine (NE) at the cardiac adrenergic neuroeffector junction was investigated in isolated hearts of rats, 6, 12 and 24 months of age. Hearts were perfused by the method of Langendorff and tyramine was administered in increasing doses as a bolus injection. There was no age-related difference in the effect of tyramine on NE release nor on the relationship between the amount of NE released and chronotropic response induced by the released NE. These findings indicate that there is no difference in the effectiveness of tyramine in promoting the release of NE from the tyramine-sensitive pool as a function of age.