Symmetrical Location Characteristics of Corticospinal Tract Associated With Hand Movement in the Human Brain: A Probabilistic Diffusion Tensor Tractography

• Published in: Medicine (Baltimore) Vol. 95; no. 15; p. e3317
• Main Authors: Lee, Dong-Hoon, Lee, Do-Wan, Han, Bong-Soo
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. Health, Inc. All rights reserved 01.04.2016; Wolters Kluwer Health
• Subjects: Adult; Brain Mapping - methods; Cerebrum - anatomy & histology; Cerebrum - physiology; Diffusion Tensor Imaging - methods; Female; Functional Laterality - physiology; Hand - innervation; Hand - physiology; Humans; Magnetic Resonance Imaging - methods; Male; Observational Study; Pyramidal Tracts - anatomy & histology; Pyramidal Tracts - physiology
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000003317

The purpose of this study is to elucidate the symmetrical characteristics of corticospinal tract (CST) related with hand movement in bilateral hemispheres using probabilistic fiber tracking method. Seventeen subjects were participated in this study. Fiber tracking was performed with 2 regions of interest, hand activated functional magnetic resonance imaging (fMRI) results and pontomedullary junction in each cerebral hemisphere. Each subject's extracted fiber tract was normalized with a brain template. To measure the symmetrical distributions of the CST related with hand movement, the laterality and anteriority indices were defined in upper corona radiata (CR), lower CR, and posterior limb of internal capsule. The measured laterality and anteriority indices between the hemispheres in each different brain location showed no significant differences with P < 0.05. There were significant differences in the measured indices among 3 different brain locations in each cerebral hemisphere with P < 0.001. Our results clearly showed that the hand CST had symmetric structures in bilateral hemispheres. The probabilistic fiber tracking with fMRI approach demonstrated that the hand CST can be successfully extracted regardless of crossing fiber problem. Our analytical approaches and results seem to be helpful for providing the database of CST somatotopy to neurologists and clinical researches.