Electrogastrography in Pediatric Functional Dyspepsia: Relationship to Gastric Emptying and Symptom Severity

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 42; no. 3; pp. 265 - 269
• Main Authors: Friesen, Craig A, Lin, Zhiyue, Hyman, Paul E, Andre, Linda, Welchert, Elly, Schurman, Jennifer Verril, Cocjin, Jose T, Burchell, Nanci, Pulliam, Shelia, Moore, Anne, Lavenbarg, Teri, McCallum, Richard W
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.03.2006; Lippincott
• Subjects: Abdominal Pain - etiology; Biological and medical sciences; Child; Dyspepsia - diagnostic imaging; Dyspepsia - physiopathology; Electrodiagnosis; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastric Emptying - physiology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Medical sciences; Myoelectric Complex, Migrating - physiology; Other diseases. Semiology; Postprandial Period; Prospective Studies; Radionuclide Imaging; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Technetium Tc 99m Sulfur Colloid; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Pediatrics; Motility; Dyspepsia; Gastric emptying; Metabolic diseases; abdominal pain- dyspepsia-motility-electrogastrogram; Abdomen; Symptomatology; Pain; Gastroenterology; Electrogastrography; Digestive diseases; Child
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/01.mpg.0000189367.99416.5e

OBJECTIVES:The aims of this study were to determine the electrogastrographic patterns in children with functional dyspepsia and to investigate the correlations among electrogastrogram (EGG), gastric emptying (GE), and pain severity. METHODS:We studied 30 children (19 F; mean age 11.4 years) with functional dyspepsia. Electrogastrography was performed for 30 minutes fasting and for 1 hour during a GE test after ingestion of an isotope-labeled solid meal. The percent emptying was measured every 10 minutes for 1 hour after the meal. The dominant frequency of the EGG, the change in the postprandial peak power (δP), and percent dysrhythmia during each recording session were calculated. Specific symptoms were graded from 0 (none) to 4 (severe) by the patient. RESULTS:Of 30 patients, 14 (47%) had slow GE, and 15 (50%) had abnormal EGG (dysrhythmia ≥ 30% or δP < 0). GE was slow in 73% of patients with an abnormal EGG but was slow in only 20% of patients with normal EGG (P = 0.009). GE was negatively correlated with fasting bradygastria (r = −0.383, P = 0.04). Abdominal pain was the most severe dyspeptic symptom, both during fasting and after the meal. Patients with an abnormal EGG had an increased mean pain severity score (3.5 ± 0.2 vs. 2.5 ± 0.2, P = 0.002). CONCLUSIONS:Sixty percent of functional dyspepsia subjects had either slow GE or abnormal EGG. Patients with abnormal EGG were more likely to have slow GE. EGG abnormalities were associated with more severe postprandial pain and should be considered a possible mechanism for dyspeptic symptoms.