Synthesis of Carbocydic Adenosine Analogs: 9-(2′,3′,4′,5′-Tetrahydroxycyclopentyl)adenines

The synthesis of five 9-(2′,3′,4′,5′-tetrahydroxycyclopentyl)adenines with 1,2,4/3,5- (2a), 1,2,3/4,5- (2b), 1,4,5/2,3- (2c), 1,4/2,3,5- (2e) and all-cis configuration (2d) are described, by animation of 4-amino-5-nitro-6-chloropyrimidine with the respective 5-aminocyclopentanetetrols (3a–e), follow...

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Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 46; no. 8; pp. 2562 - 2564
Main Authors Suami, Tetsuo, Nishiyama, Shigeru, Tadano, Kinichi, Lichtenthaler, Frieder W
Format Journal Article
LanguageEnglish
Published The Chemical Society of Japan 1973
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Summary:The synthesis of five 9-(2′,3′,4′,5′-tetrahydroxycyclopentyl)adenines with 1,2,4/3,5- (2a), 1,2,3/4,5- (2b), 1,4,5/2,3- (2c), 1,4/2,3,5- (2e) and all-cis configuration (2d) are described, by animation of 4-amino-5-nitro-6-chloropyrimidine with the respective 5-aminocyclopentanetetrols (3a–e), followed by reduction of the nitro group and cyclization with formamide. Prelimimnary anyifungal properties are reported.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.46.2562