Induction with azacytidine followed by allogeneic hematopoietic stem cell transplantation in a Jehovah's Witness with acute monocytic leukemia

• Published in: Clinical case reports Vol. 3; no. 5; pp. 287 - 290
• Main Authors: Garelius, Hege, Grund, Sofia, Stockelberg, Dick
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2015; BlackWell Publishing Ltd
• Subjects: Abortion; Acute myeloid leukemia; allogeneic transplantation; azacitidine; Blood platelets; Blood products; Bone marrow; Case Reports; Chemotherapy; Flow cytometry; Hemoglobin; Iron; Jehovah's Witnesses; Jehovahs Witnesses; Leukemia; Mutation; Patients; Skin; Stem cells; Transplants & implants; Sweden; allogeneic transplantation; Jehovah's Witnesses; Acute myeloid leukemia; azacitidine
• ISSN: 2050-0904; 2050-0904
• DOI: 10.1002/ccr3.212

Key Clinical Message We have used a hypomethylating agent instead of conventional chemotherapy to induce remission in a young Jehovah's Witness with acute monocytic leukemia to avoid severe myelosuppression and blood product support. The treatment was consolidated with reduced intensity allogeneic stem cell transplantation. This could be an alternative when transfusions must be avoided. We have used a hypomethylating agent instead of conventional chemotherapy to induce remission in a young Jehovah's Witness with acute monocytic leukemia to avoid severe myelosuppression and blood product support. The treatment was consolidated with reduced intensity allogeneic stem cell transplantation. This could be an alternative when transfusions must be avoided.