Solvation thermodynamics of anti-tuberculosis Isoniazid in aqueous and in aqueous electrolytic media

• Published in: The Journal of chemical thermodynamics Vol. 123; pp. 128 - 139
• Main Authors: Malladi, Latha, Tangde, Vijay M., Dhondge, Sudhakar S., Sheikh, Nikhat
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2018
• Subjects: Density; Isoniazid (INH); Potassium chloride; Sodium chloride; Speed of sound; Isoniazid (INH); Speed of sound; Sodium chloride; Density; Potassium chloride
• ISSN: 0021-9614; 1096-3626
• DOI: 10.1016/j.jct.2018.04.003

[Display omitted] •Density and speeds of sound are measured for Isoniazid in water and salt solutions.•Solvation behavior of INH in aqueous sodium chloride and potassium chloride.•Co-sphere overlap model is used to understand the transfer properties.•Hepler’s constant indicated structure making ability of Isoniazid in studied systems. Isoniazid forms one of the most potent antitubercular drugs effective against M. tuberculosis which functions in combination with pyrazinamide, rifampicin and ethambutol drugs. A drug is subjected to many complex processes from the time it is administered to the time the biologic response is affected. The physical properties give an idea of various types of interactions taking place between drug and water molecule. Keeping this in mind we have measured densities (ρ) and speeds of sound (u) of Isoniazid (INH) in aqueous, aqueous sodium chloride and potassium chloride (0.06 mol·kg−1 and 0.1 mol·kg−1 in water) at three different temperatures i.e. T = (288.15, 298.15 and 308.15) K in the concentration range of (0.01 to 0.1) mol·kg−1. From these experimental data, apparent molar volume (Vϕ) of solute, isentropic compressibility (κs) of solution, apparent molar isentropic compressibility (κϕ) of Isoniazid (INH) in water and in aqueous solutions of 0.06 and 0.1 mol·kg−1 sodium chloride and potassium chloride have been calculated. The limiting apparent molar expansivity (Eϕ0) of solute and coefficient of thermal expansion (α∗) of Isoniazid (INH) have also been calculated. Transfer parameters have been interpreted from the point of view of concentration dependence of solute–solvent interactions. Infinite dilution values of Vϕ and κϕ have also obtained from extrapolation to zero molality and have been utilized in obtaining transfer volumes (ΔtrVϕ0) and transfer compressibility (Δtrκϕ0) of Isoniazid (INH) from aqueous solutions of 0.06 mol·kg−1 and 0.1 mol·kg−1 sodium chloride and potassium chloride at different temperatures. Results are used to analyze the nature of solute-solvent, solute-solute interaction and structure making/breaking ability of solute in the aqueous solution.