Catalytic asymmetric synthesis of alpha- and beta-amino phosphonic acid derivatives

Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding alpha- and beta-amino acids, optically active alpha- and beta-amino phosphonic acid derivatives have found...

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Bibliographic Details
Published inChemical Society reviews Vol. 35; no. 7; p. 630
Main Author Ma, Jun-An
Format Journal Article
LanguageEnglish
Published England 22.06.2006
Subjects
Catalysis
Imines - chemistry
Ligands
Molecular Structure
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Oxidation-Reduction
Stereoisomerism
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Summary:Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding alpha- and beta-amino acids, optically active alpha- and beta-amino phosphonic acid derivatives have found widespread use in medicinal chemistry and the pharmaceutical sciences. Using catalytic amounts of chiral materials, asymmetric synthesis of enantiomerically enriched alpha- and beta-amino phosphonates has been a subject of growing interest. This tutorial review contains a compilation of the catalytic asymmetric synthetic methods developed to date and highlights their utility for obtaining these target compounds.
ISSN:0306-0012
DOI:10.1039/b517100h