The role of HMGB1 in inflammation-mediated organ injury

HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the re...

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Published inActa anaesthesiologica Taiwanica Vol. 51; no. 1; pp. 28 - 33
Main Authors Asavarut, Paladd, Zhao, Hailin, Gu, Jianteng, Ma, Daqing
Format Journal Article
LanguageEnglish
Published China (Republic : 1949- ) Elsevier B.V 01.03.2013
Subjects
Animals
Atherosclerosis - etiology
Cardiomyopathies - etiology
Glycation End Products, Advanced - physiology
Graft Rejection - etiology
HMGB1 protein
HMGB1 Protein - physiology
Humans
inflammation
Inflammation - etiology
Neurodegenerative Diseases - etiology
organ injuries
Reperfusion Injury - etiology
Stress, Mechanical
Toll-Like Receptor 4 - physiology
inflammation
organ injuries
HMGB1 protein
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Summary:HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the receptor for advanced glycation end-products in organ injury. HMGB1-mediated organ injuries are acute damage including ischemic, mechanical, allograft rejection and toxicity, and chronic diseases of the heart, kidneys, lungs, and brain. Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1875-4597
1875-452X
DOI:10.1016/j.aat.2013.03.007