Ternary nanofiber matrices composed of PCL/black phosphorus/collagen to enhance osteodifferentiation

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 80; pp. 802 - 810
• Main Authors: Lee, Yu Bin, Song, Su-Jin, Shin, Yong Cheol, Jung, Yu Jin, Kim, Bongju, Kang, Moon Sung, Kwon, Il Keun, Hyon, Suong-Hyu, Lee, Hyun Uk, Jung, Seo-Hyun, Lim, Dohyung, Han, Dong-Wook
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.12.2019; 한국공업화학회
• Subjects: Black phosphorus; Bone tissue engineering; Collagen; Nanofiber matrices; Polycaprolactone; 화학공학; Nanofiber matrices; Bone tissue engineering; Polycaprolactone; Collagen; Black phosphorus
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2019.06.055

[Display omitted] •Black phosphorus (BP)-incorporated PCL and collagen nanofiber matrix is designed.•PCL/BP/Col nanofiber matrix favorably supports cell growth.•Biocompatibility and biofunctionality of PCL/BP/Col matrix is demonstrated.•PCL/BP/Col matrix can stimulate spontaneous osteodifferentiation.•PCL/BP/Col matrix can be employed as a bone tissue engineering scaffold. Recently, considerable research has been made on the development of bone tissue engineering (BTE) scaffolds to support cellular behaviors. Here, black phosphorus-incorporated poly(ε-caprolactone) and collagen (PCL/BP/Col) nanofiber matrices were designed and their potential as BTE scaffolds were explored. The PCL/BP/Col nanofiber matrices were fabricated successfully by electrospinning, showing that they were suitable for supporting cell growth. The PCL/BP/Col nanofiber matrices could promote not only initial attachment and proliferation, but also osteodifferentiation of preosteoblasts. In conclusion, PCL/BP/Col nanofiber matrices possess excellent biocompatibility and improve osteogenic differentiation. Therefore, the PCL/BP/Col nanofiber matrices can be a promising candidate as a scaffold for BTE.