Adsorptive stripping voltammetric determination of antihypertensive agent : diltiazem

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 25; no. 3-4; pp. 443 - 451
• Main Authors: GHANDOUR, M. A, ENSAF ABOUL KASIM, ALIA, Azza M. M, EL-HATY, M. T, AHMED, Mahasen M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Science 01.06.2001
• Subjects: Analysis; Antihypertensive agents; Antihypertensive Agents - analysis; Biological and medical sciences; Capsules; Cardiovascular system; Diltiazem - analysis; Diltiazem - urine; Electrochemistry; General pharmacology; Humans; Medical sciences; Pharmacology. Drug treatments; Human; Urine; Biological fluid; Benzothiazepine derivatives; Metal ion; Capsule; Diltiazem; Normal; Cathodic stripping voltammetry; Cyclic voltammetry; Adsorption; Aminoacid; Concentration effect; Dosage form; Antihypertensive agent; Quantitative analysis

Adsorptive stripping voltammetry was used to determine the antihypertensive agent diltiazem in phosphate buffer (pH 7.0). The adsorptive cathodic peak was observed at -1.72 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, accumulat...