Adsorptive stripping voltammetric determination of antihypertensive agent : diltiazem

Adsorptive stripping voltammetry was used to determine the antihypertensive agent diltiazem in phosphate buffer (pH 7.0). The adsorptive cathodic peak was observed at -1.72 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, accumulat...

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Bibliographic Details
Published inJournal of pharmaceutical and biomedical analysis Vol. 25; no. 3-4; pp. 443 - 451
Main Authors GHANDOUR, M. A, ENSAF ABOUL KASIM, ALIA, Azza M. M, EL-HATY, M. T, AHMED, Mahasen M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Science 01.06.2001
Subjects
Analysis
Antihypertensive agents
Antihypertensive Agents - analysis
Biological and medical sciences
Capsules
Cardiovascular system
Diltiazem - analysis
Diltiazem - urine
Electrochemistry
General pharmacology
Humans
Medical sciences
Pharmacology. Drug treatments
Human
Urine
Biological fluid
Benzothiazepine derivatives
Metal ion
Capsule
Diltiazem
Normal
Cathodic stripping voltammetry
Cyclic voltammetry
Adsorption
Aminoacid
Concentration effect
Dosage form
Antihypertensive agent
Quantitative analysis
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Summary:Adsorptive stripping voltammetry was used to determine the antihypertensive agent diltiazem in phosphate buffer (pH 7.0). The adsorptive cathodic peak was observed at -1.72 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, accumulation potential and supporting electrolytes. The obtained results were analyzed and the statistical parameters were calculated. The proposed method was applied to determine the mentioned drug in pharmaceutical formulation (capsule) and urine. The detection limit is 1x10(-8) M (4.5 ng ml(-1)) using 180 s preconcentration time, whereas the lower limit of detection is 6x10(-9) M (2.7 ng ml(-1)).
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ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(00)00594-X