An alternative synthesis of clindamycin

A novel synthesis of clindamycin from lincomycin using N-chlorosuccinimide and triphenylphosphine is reported. This results in high yields and avoids the use of tetrachloromethane employed in the current manufacturing process. This article has been corrected. Link to the correction 10.2298/JSC001297...

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Bibliographic Details
Published inJournal of the Serbian Chemical Society Vol. 65; no. 10; pp. 691 - 694
Main Authors Bowden, Keith, Stevens, Graham
Format Journal Article
LanguageEnglish
Published Serbian Chemical Society 2000
Subjects
clindamycin
n-chlorosuccinmide
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Summary:A novel synthesis of clindamycin from lincomycin using N-chlorosuccinimide and triphenylphosphine is reported. This results in high yields and avoids the use of tetrachloromethane employed in the current manufacturing process. This article has been corrected. Link to the correction 10.2298/JSC0012975E nema
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC0010691B