Preparation of hydroxypropyl-β-cyclodextrin-incorporated liposomes and evaluation of their rapid release property

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 100; pp. 59 - 62
• Main Authors: Lim, Hana, Jin, Soyeong, Jeong, Youngdo, Kim, Seong-Bo, Jang, Dong-Jin, Kim, Sung Tae
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.08.2021; 한국공업화학회
• Subjects: Ceftazidime; Hydroxypropyl-β-cyclodextrin; Liposome; Rapid release; 화학공학; Liposome; Hydroxypropyl-β-cyclodextrin; Rapid release; Ceftazidime
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2021.05.002

[Display omitted] The aim of this study was to investigate the effect of hydroxypropyl-β-cyclodextrin (HPβCD), widely used as a solubility enhancer, on liposomal formulations. To this end, HPβCD was added to fabricate liposomes during the hydration process, and their physicochemical properties were evaluated. The Fourier transform infrared and nuclear magnetic resonance spectra revealed that HPβCD could interact with the model drug, ceftazidime (CAZ), and with phosphatidylcholine, a main component of liposomes. This leads to a rapid release of CAZ depending on the concentration of HPβCD. Nanosized HPβCD-incorporated liposomes complied with Korsmeyer–Peppas kinetics, and the release of drug increased without significant changes in the release pattern. Our approach, which relied on supramolecule-related interactions, could provide new insights into other lipid-based formulations for accelerating drug-release properties.