Pharmacokinetics and bioavailability of a long-acting formulation of cephalexin after intramuscular administration to cats

• Published in: Research in veterinary science Vol. 91; no. 1; pp. 129 - 131
• Main Authors: Albarellos, G.A., Montoya, L., Quaine, P.C., Landoni, M.F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2011; Elsevier Limited
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Bioavailability; Biological Availability; Cats; Cephalexin; Cephalexin - administration & dosage; Cephalexin - blood; Cephalexin - pharmacokinetics; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Drug therapy; Injections, Intramuscular - veterinary; Injections, Intravenous - veterinary; Intramuscular; Long-acting formulation; Pharmacokinetics; Veterinary medicine; Argentina; Cats; Long-acting formulation; Intramuscular; Bioavailability; Pharmacokinetics; Cephalexin
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2010.08.001

The pharmacokinetic profile and bioavailability of a long-acting formulation of cephalexin after intramuscular administration to cats was investigated. Single intravenous (cephalexin lysine salt) and intramuscular (20% cephalexin monohydrate suspension) were administered to five cats at a dose rate of 10mg/kg. Serum disposition curves were analyzed by noncompartmental approaches. After intravenous administration, volume of distribution (Vz), total body clearance (Clt), elimination constant (λz), elimination half-life (t½λ) and mean residence time (MRT) were: 0.33±0.03L/kg; 0.14±0.02L/hkg, 0.42±0.05h−1, 1.68±0.20h and 2.11±0.25h, respectively. Peak serum concentration (Cmax), time to peak serum concentration (Tmax) and bioavailability after intramuscular administration were 15.67±1.95μg/mL, 2.00±0.61h and 83.33±8.74%, respectively.