Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water

A catalyst-free thiolation of indoles with sulfonyl hydrazides was efficiently developed in water under mild conditions without any ligand or additive. The reaction provided a variety of 3-sulfenylindoles with good to excellent yields and the only by-products were nitrogen and water.

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Bibliographic Details
Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 18; no. 9; pp. 2609 - 2613
Main Authors Yang, Yu, Zhang, Sheng, Tang, Lin, Hu, Yanbin, Zha, Zhenggen, Wang, Zhiyong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Additives
Byproducts
Catalysts
Chemistry
Chemistry, Multidisciplinary
Green & Sustainable Science & Technology
Hydrazides
Indoles
Ligands
Physical Sciences
Science & Technology
Science & Technology - Other Topics
Synthesis
FUNCTIONALIZATION
ORGANIC-SYNTHESIS
C-H BOND
PROMOTED SULFENYLATION
GREEN CHEMISTRY
LIGHT
CHLORIDES
TERMINAL ALKYNES
ARYL SULFONES
HIGHLY EFFICIENT
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Summary:A catalyst-free thiolation of indoles with sulfonyl hydrazides was efficiently developed in water under mild conditions without any ligand or additive. The reaction provided a variety of 3-sulfenylindoles with good to excellent yields and the only by-products were nitrogen and water.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1463-9262
1463-9270
DOI:10.1039/c6gc00313c