Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

• Published in: Neuropsychobiology Vol. 76; no. 4; p. 193
• Main Authors: Genis-Mendoza, Alma Delia, López-Narvaez, María Lilia, Tovilla-Zárate, Carlos Alfonso, Sarmiento, Emmanuel, Chavez, Adriana, Martinez-Magaña, Jose Jaime, González-Castro, Thelma Beatriz, Hernández-Díaz, Yazmín, Juárez-Rojop, Isela Esther, Ávila-Fernández, Ángela, Nicolini, Humberto
• Format: Journal Article
• Language: English
• Published: Switzerland 2017
• Subjects: DRD2 gene; ANKK1 gene; Dopamine; Gene; Suicide
• ISSN: 1423-0224
• DOI: 10.1159/000490071

The aim of this study was to analyze the possible association of polymorphic variants of the DRD2 and ANKK1 genes with suicide attempt in a Mexican population. We conducted a case-control study in 289 subjects (166 suicide attempters and 123 healthy controls). We genotyped 2 polymorphisms of DRD2 (rs6275 and rs1799978) and 1 polymorphism of ANKK1 (rs1800497); then we analyzed the association between suicide attempt and these polymorphisms through genotypes, alleles, and inheritance models. Individuals who carried the TT genotype of the rs1800497 showed a 3-fold risk of attempting suicide (OR = 3.01; 95% CI 1.56-5.81, p = 0.001) when evaluated through the recessive model. In an analysis stratified by gender, this risk factor remained present among females (OR = 2.81; 95% CI 1.37-5.75) as well as males (OR = 3.3; 95% CI 1.01-10.77). Our results suggest that the rs1800497 variant of the ANKK1 gene could increase the risk of suicide attempt in a Mexican population. However, further studies using larger samples are necessary to obtain more conclusive results.