Evaluation of cardiotoxicity via speckle-tracking echocardiography in patients treated with anthracyclines

• Published in: Onkologie Vol. 36; no. 12; p. 712
• Main Authors: Dogru, Atalay, Cabuk, Devrim, Sahin, Tayfun, Dolasik, Ilhan, Temiz, Suleyman, Uygun, Kazim
• Format: Journal Article
• Language: English
• Published: Switzerland 01.12.2013
• Subjects: Adult; Anthracyclines - adverse effects; Anthracyclines - therapeutic use; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Breast Neoplasms - complications; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Cardiomyopathies - chemically induced; Cardiomyopathies - diagnostic imaging; Echocardiography - methods; Elasticity Imaging Techniques - methods; Female; Humans; Lymphoma - complications; Lymphoma - diagnostic imaging; Lymphoma - drug therapy; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome
• ISSN: 1423-0240
• DOI: 10.1159/000356850

The aim of this study was to examine the cardiac effects of anthracycline therapy based on speckle-tracking echocardiography (STE) and to identify patients at risk for cardiotoxicity. The study included 35 breast cancer (BC) and 15 lymphoma patients who were treated with anthracycline-based chemotherapy. Conventional echocardiography and STE were performed 1 month prior to and 1 month after chemotherapy. Longitudinal strain analysis was performed via STE using automated functional imaging. The ejection fraction (EF) and the fractional shortening values were significantly lower in the lymphoma group. There was a positive correlation between anthracycline dose and subclinical heart failure (p = 0.024). There was an increase in the myocardial performance index in both groups. After therapy, STE showed regional decreases in the longitudinal strain values in the BC group, but the global strain values did not differ. In the lymphoma group, the apical long-axis, the 4-chamber, and the global longitudinal strain values were significantly lower after therapy (p = 0.002, 0.041, and 0.004, respectively). The long-axis and global longitudinal strain values were significantly lower in the lymphoma patients with normal EF values (p = 0.01 and 0.05, respectively). Cardiotoxicity during the early phase of anthracycline treatment can be detected via STE prior to the observation of systolic function deterioration.