Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions
The regio- and stereoselective ring-opening of spiro-epoxyoxindoles with ammonia has been reported for the construction of 3-hydroxy-3-aminomethyloxindoles in high yields (up to 90%) and enantioselectivities (up to 99% ee) under mild and catalyst-free conditions. The reaction could be scaled up to t...
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Published in | Green chemistry : an international journal and green chemistry resource : GC Vol. 19; no. 9; pp. 2107 - 2110 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
2017
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Subjects | |
Online Access | Get full text |
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Summary: | The regio- and stereoselective ring-opening of spiro-epoxyoxindoles with ammonia has been reported for the construction of 3-hydroxy-3-aminomethyloxindoles in high yields (up to 90%) and enantioselectivities (up to 99% ee) under mild and catalyst-free conditions. The reaction could be scaled up to the gram-scale and be used in the synthesis of analogues of dioxibrassinin and spirobrassinin. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1463-9262 1463-9270 |
DOI: | 10.1039/c7gc00438a |