Visibility of esophageal squamous cell carcinoma under iodine staining on texture and color enhancement imaging

• Published in: DEN open Vol. 5; no. 1; p. e370
• Main Authors: Kato, Tsunetaka, Hikichi, Takuto, Nakamura, Jun, Hashimoto, Minami, Kobashi, Ryoichiro, Yanagita, Takumi, Takagi, Tadayuki, Suzuki, Rei, Sugimoto, Mitsuru, Asama, Hiroyuki, Sato, Yuki, Shioya, Yasuo, Kobayakawa, Masao, Ohira, Hiromasa
• Format: Journal Article
• Language: English
• Published: Australia John Wiley and Sons Inc 01.04.2025
• Subjects: Original; esophageal squamous cell carcinoma; color difference; endoscopic diagnosis; texture and color enhancement imaging; iodine staining
• ISSN: 2692-4609; 2692-4609
• DOI: 10.1002/deo2.370

Iodine staining on white light imaging (WLI) is the gold standard for detecting and demarcating esophageal squamous cell carcinoma (ESCC). We examined the effects of texture and color enhancement imaging (TXI) on improving the endoscopic visibility of ESCC under iodine staining. Twenty ESCC lesions that underwent endoscopic submucosal dissection were retrospectively included. The color difference between ESCC and the surrounding mucosa ( e) on WLI, TXI, and narrow-band imaging was assessed, and e under 1% iodine staining on WLI and TXI. Furthermore, the visibility grade determined by endoscopists was evaluated on each imaging. The median e was greater on TXI than on WLI (14.53 vs. 10.71, respectively; < 0.005). Moreover, the median e on TXI under iodine staining was greater than the median e on TXI and narrow-band imaging (39.20 vs. 14.53 vs. 16.42, respectively; < 0.005 for both). A positive correlation in e under iodine staining was found between TXI and WLI (correlation coefficient = 0.61, < 0.01). Moreover, e under iodine staining on TXI in each lesion was greater than the corresponding e on WLI. The visibility grade assessed by endoscopists on TXI was also significantly greater than that on WLI under iodine staining ( < 0.01). The visibility of ESCC after iodine staining was greater on TXI than on WLI.