Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal filler for anti-ageing treatment

[Display omitted] Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel p...

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Bibliographic Details
Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 65; pp. 363 - 369
Main Authors Zhang, Jia Nan, Chen, Bo Zhi, Ashfaq, Mohammad, Zhang, Xiao Peng, Guo, Xin Dong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.09.2018
한국공업화학회
Subjects
Anti-ageing
Cosmetic
Hyaluronic acid
Microneedle
Skin
화학공학
Cosmetic
Anti-ageing
Skin
Hyaluronic acid
Microneedle
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Summary:[Display omitted] Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel particles decrease the mechanical properties of MNs. The in-vitro degradation profile and in-vivo epidermal expansion in mice were also carried out. The data suggested that the proportion of cHA particles decreased the rate of MNs degradation. The prepared HA-cHA-MNs have prolonged effectiveness with high swelling retention time or epidermal expansion time in mice up to 6days or more.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2018.05.007