Functionalized inclined-GaN based nanoneedles

[Display omitted] Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods...

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Bibliographic Details
Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 59; pp. 184 - 191
Main Authors Kim, Kwon-Ho, Lee, Kyuseung, Hong, Hyeonaug, Yang, Dasom, Ryu, WonHyoung, Nam, Okhyun, Kim, Yeu-Chun
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.03.2018
한국공업화학회
Subjects
Cell insertion
Inclined-GaN
Intracellular delivery
Nanoneedle
Surface functionalization
화학공학
Surface functionalization
Inclined-GaN
Nanoneedle
Intracellular delivery
Cell insertion
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Summary:[Display omitted] Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods, one-dimensional nanoneedles are one of the promising methods for insertion with minimal invasiveness to a cell. Most of the previous studies have been conducted using vertical nanoneedle. Here, we synthesized new inclined nanoneedles and demonstrated a novel platform using inclined-gallium nitride nanoneedles (iGaN NNs) to facilitate efficient intracellular delivery. In our system, foreign molecules were successfully delivered into cytoplasm of a cell through the penetration of the cell membrane by the iGaN NNs.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2017.10.022