Photoprotective Properties of the Fluorescent Europium Complex in UV-Irradiated Skin

In this study, we compared the UV-protective abilities of the europium complex compared to titanium dioxide, which represents the most common physical filter for ultraviolet light in the broad-band spectral range. The UV absorption and light transformative capacities of the europium complex were eva...

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Published inSkin pharmacology and physiology Vol. 26; no. 2; pp. 76 - 84
Main Authors Vogt, O., Lademann, J., Rancan, F., Meinke, M.C., Schanzer, S., Stockfleth, E., Sterry, W., Lange-Asschenfeldt, B.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2013
Subjects
Adult
Animals
Biological Transport
Cell Membrane Permeability - drug effects
Cell Survival - drug effects
Europium - pharmacology
Female
Humans
Jurkat Cells
Metal Nanoparticles - administration & dosage
Original Paper
Skin - metabolism
Skin - radiation effects
Skin Absorption
Sunscreening Agents - pharmacology
Swine
Titanium - pharmacology
Ultraviolet Rays
Sunscreen
Europium complex
Ultraviolet filter
Titanium dioxide
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Summary:In this study, we compared the UV-protective abilities of the europium complex compared to titanium dioxide, which represents the most common physical filter for ultraviolet light in the broad-band spectral range. The UV absorption and light transformative capacities of the europium complex were evaluated using a spectrometer with a double-integrating sphere showing that the europium complex does not only absorb and reflect UV light, but transforms it into red and infrared light. It was found that the europium complex binds to the surface of Jurkat cells in vitro. Cells incubated with the europium complex showed a significantly higher viability after UVA and UVB irradiation as compared to untreated cells and cells incubated with titanium dioxide pointing out its photoprotective properties. The europium complex and titanium dioxide show similar penetration capacities into the stratum corneum as tested in human and porcine skin using tape stripping analysis. The europium complex has proved to be an efficient UV filter with a low cyto- and phototoxic profile and therefore represents a potential candidate for use in sunscreen formulations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1660-5527
1660-5535
DOI:10.1159/000345976