Effect of Salt Intake and Potassium Supplementation on Urinary Renalase and Serum Dopamine Levels in Chinese Adults

• Published in: Cardiology Vol. 130; no. 4; pp. 242 - 248
• Main Authors: Wang, Yang, Wang, Dan, Chu, Chao, Mu, Jian-Jun, Wang, Man, Liu, Fu-Qiang, Xie, Bing-Qing, Yang, Fan, Dong, Zhen-Zhen, Yuan, Zu-Yi
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Adult; Aged; Asian Continental Ancestry Group; Blood Pressure - physiology; China; Dopamine - blood; Female; Humans; Hypertension - prevention & control; Male; Middle Aged; Monoamine Oxidase - urine; Original Research; Potassium; Potassium - administration & dosage; Prospective Studies; Rural Population; Salt; Sodium Chloride, Dietary - administration & dosage; Sodium Chloride, Dietary - urine; Studies; Urine; China; Urine; Salt; Renalase; Dopamine; Potassium
• ISSN: 0008-6312; 1421-9751
• DOI: 10.1159/000371794

Objective: The aim of our study was to assess the effects of altered salt and potassium intake on urinary renalase and serum dopamine levels in humans. Methods: Forty-two subjects (28-65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for an additional 7 days (18.0 g/day of NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day of NaCl + 4.5 g/day of KCl). Results: Urinary renalase excretions were significantly higher during the high-salt diet intervention than during the low-salt diet. During high-potassium intake, urinary renalase excretions were not significantly different from the high-salt diet, whereas they were significantly higher than the low-salt levels. Serum dopamine levels exhibited similar trends across the interventions. Additionally, a significant positive relationship was observed between the urine renalase and serum dopamine among the different dietary interventions. Also, 24-hour urinary sodium excretion positively correlated with urine renalase and serum dopamine in the whole population. Conclusions: The present study indicates that dietary salt intake and potassium supplementation increase urinary renalase and serum dopamine levels in Chinese subjects.