Hemolytic anemia after zopiclone overdose

Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. Case. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, rais...

Full description

Saved in:
Bibliographic Details
Published inClinical toxicology (Philadelphia, Pa.) Vol. 47; no. 9; pp. 902 - 903
Main Authors Fung, Hin Tat Jeffrey, Lai, Cing Hon, Wong, Oi Fung, Lam, Shing Kit Tommy, Lam, Ka Keung
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.11.2009
Taylor & Francis
Subjects
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - physiopathology
Azabicyclo Compounds - poisoning
Drug Overdose
Female
Follow-Up Studies
Hemolysis
Humans
Hypnotics and Sedatives - poisoning
Methemoglobinemia
Middle Aged
Oxidative Stress - drug effects
Piperazines - poisoning
Zopiclone
Online AccessGet full text

Cover

Abstract Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. Case. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis. Discussion. In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
AbstractList Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. Case. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis. Discussion. In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis. In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
Author Fung, Hin Tat Jeffrey
Lai, Cing Hon
Lam, Shing Kit Tommy
Wong, Oi Fung
Lam, Ka Keung
Author_xml – sequence: 1
  givenname: Hin Tat Jeffrey
  surname: Fung
  fullname: Fung, Hin Tat Jeffrey
  email: funght@ha.org.hk
  organization: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China
– sequence: 2
  givenname: Cing Hon
  surname: Lai
  fullname: Lai, Cing Hon
  email: funght@ha.org.hk
  organization: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China
– sequence: 3
  givenname: Oi Fung
  surname: Wong
  fullname: Wong, Oi Fung
  email: funght@ha.org.hk
  organization: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China
– sequence: 4
  givenname: Shing Kit Tommy
  surname: Lam
  fullname: Lam, Shing Kit Tommy
  email: funght@ha.org.hk
  organization: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China
– sequence: 5
  givenname: Ka Keung
  surname: Lam
  fullname: Lam, Ka Keung
  email: funght@ha.org.hk
  organization: Accident & Emergency Department, Tuen Mun Hospital, Hong Kong, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19821637$$D View this record in MEDLINE/PubMed
BookMark eNp9kE1LxDAQhoOsuB_6A7xIrx6qmU6TbtCLLH7Bghc9l7SZsF3aZkm6yvrrbdkFEdHTDJP3eSfvTNmodS0xdg78CoGraxBCohRccURAkcIRmwyzWAlQo0M_CMZsGsKac5ynCk7YGNQ8AYnZhF0-UePqXVeVkW6pqXSkbUc--nSbqqz7dZF7J29coFN2bHUd6OxQZ-zt4f518RQvXx6fF3fLuERMu1hayQuUZABQSwtACRciyfrHVElpEQrgKArL1Ry4STNlM4mJBmsStCbFGYO9b-ldCJ5svvFVo_0uB54PsfNfsXvmYs9stkVD5ps45OwFt3tB1VrnG_3hfG3yTu9q563XbVmFwftv_5sf-Ip03a1K7Slfu61v-3v887svWQJ3ew
CitedBy_id crossref_primary_10_7759_cureus_54224
crossref_primary_10_1097_PAT_0000000000000258
crossref_primary_10_1007_s13181_013_0292_0
crossref_primary_10_1007_s00228_013_1557_x
Cites_doi 10.2165/00139709-200423030-00004
10.1080/15563650701305558
10.1080/15563650802382175
ContentType Journal Article
Copyright Informa UK, Ltd. 2009
Copyright_xml – notice: Informa UK, Ltd. 2009
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
DOI 10.3109/15563650903313541
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
DatabaseTitleList

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Public Health
EISSN 1556-9519
EndPage 903
ExternalDocumentID 10_3109_15563650903313541
19821637
431528
Genre Brief Communications
Journal Article
Case Reports
GroupedDBID ---
.GJ
00X
03L
0BK
0R~
29B
34G
36B
39C
3O-
4.4
53G
5RE
5VS
AAJNR
AALIY
AALUX
AAMIU
AAPUL
AAQRR
ABBKH
ABCRQ
ABDBF
ABEIZ
ABLKL
ABPTK
ABUPF
ACENM
ACFUF
ACGFS
ACLSK
ADCVX
ADFCX
ADRBQ
AECIN
AENEX
AEOZL
AEYQI
AFKVX
AFWLO
AGAFX
AGDLA
AGFJD
AGRBW
AGYJP
AIJEM
AIRBT
AJEBJ
AJWEG
AKBVH
ALIIL
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AWYRJ
BABNJ
BLEHA
BOHLJ
CAG
CCCUG
COF
DEIEU
DKSSO
DTRLO
DU5
DZHFC
EAP
EAS
EBC
EBD
EBS
EDH
EHN
EJD
EMB
EMK
EMOBN
EPL
EPT
ESX
F5P
H13
HZ~
J.N
KRBQP
KSSTO
KWAYT
KYCEM
LJTGL
LSO
M44
M4Z
O9-
QRXOQ
Q~Q
RNANH
RVRKI
SV3
TFDNU
TFL
TFW
TUS
UHWXJ
V1S
~1N
ABJNI
ABLIJ
ABXYU
ALYBC
CGR
CUY
CVF
ECM
EIF
NPM
NUSFT
TBQAZ
TERGH
AAYXX
ACIEZ
CITATION
TDBHL
TUROJ
ID FETCH-LOGICAL-c334t-6f60b36ed113a6f11e2055273344966f31b1035bf09810d479f7632a1fd23fd43
ISSN 1556-3650
IngestDate Fri Aug 23 01:28:06 EDT 2024
Thu May 23 23:13:28 EDT 2024
Tue Jun 13 19:21:17 EDT 2023
Wed Jun 21 01:43:56 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c334t-6f60b36ed113a6f11e2055273344966f31b1035bf09810d479f7632a1fd23fd43
PMID 19821637
PageCount 2
ParticipantIDs informahealthcare_journals_10_3109_15563650903313541
informaworld_taylorfrancis_310_3109_15563650903313541
pubmed_primary_19821637
crossref_primary_10_3109_15563650903313541
PublicationCentury 2000
PublicationDate 20091100
11/1/2009
2009-Nov
2009-11-00
PublicationDateYYYYMMDD 2009-11-01
PublicationDate_xml – month: 11
  year: 2009
  text: 20091100
PublicationDecade 2000
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Clinical toxicology (Philadelphia, Pa.)
PublicationTitleAlternate Clin Toxicol (Phila)
PublicationYear 2009
Publisher Informa UK Ltd
Taylor & Francis
Publisher_xml – name: Informa UK Ltd
– name: Taylor & Francis
References CIT0003
CIT0002
CIT0001
References_xml – ident: CIT0001
  doi: 10.2165/00139709-200423030-00004
– ident: CIT0002
  doi: 10.1080/15563650701305558
– ident: CIT0003
  doi: 10.1080/15563650802382175
SSID ssj0038491
Score 1.9466974
Snippet Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication,...
Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. A...
SourceID crossref
pubmed
informaworld
informahealthcare
SourceType Aggregation Database
Index Database
Publisher
StartPage 902
SubjectTerms Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - physiopathology
Azabicyclo Compounds - poisoning
Drug Overdose
Female
Follow-Up Studies
Hemolysis
Humans
Hypnotics and Sedatives - poisoning
Methemoglobinemia
Middle Aged
Oxidative Stress - drug effects
Piperazines - poisoning
Zopiclone
Title Hemolytic anemia after zopiclone overdose
URI https://www.tandfonline.com/doi/abs/10.3109/15563650903313541
https://www.ncbi.nlm.nih.gov/pubmed/19821637
Volume 47
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdZ-zIYo-u-uo_ih71swZllSbb02HYNZoNtsBT6ZixLooEmDqsHW9kfv5MlfyRZR7sXE4R0dnQ_S3fnu58QelNEhOqUMwCvBAdFGR3KImWh4aXCKsEqLpss389JdkY_nrPz0ej3sLqklpPy-q91Jf-jVWgDvdoq2TtothMKDfAb9AtX0DBcb6XjTC-qy1-OclUvbHlVc-L3dbWCnhWYjzY_U1VX63wEbS1kXf2cl46CCcxMG1mxlJGrC5c--7WYDKIEU78mZPPleFbUbQFYl87jDrU-sXGHrP-w3-b7fpmPrYC-dwPCb03w69O8Hs-qhS-saOMPwhfiDZZMloQkcfSxE923ge0mhuusY9b0eBKDRVNE8WD_FQ3nwdbSThwzqpVsbwa9CCbMkWat02hvbG9d0iG4O1ZIviXiHtqNU8HAdd89Ov5wPG13csKpcHy7_h-6r-JWyPstIWt2zZ5nvb3ocvg2mHA3nJjGmJntoYfeCwmOHKQeoZFe7qMHLoQbuMq0x-htB6_AwSto4BV08ApaeD1BZ9PT2UkW-pM1wpIQWoeJSSJJEq0wJkViMNZx1FDxEUrB_zUESxwRJk0kOI4UTYWBfSgusFExMYqSp2hnCfd5jgJeSFzyMhIl0zQt0oIyHkmegKNcGsL5AXrXzku-cgQq-Y2aOEB0a-Zy_8Jd_WsYG05uXjfBLuNOprFjbhz3zGmhfzLBY_BQ0hd3eeqX6H7_YrxCO_X3H_o1mKq1PPSI-gOKZYXv
link.rule.ids 315,786,790,27957,27958
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hemolytic+anemia+after+zopiclone+overdose&rft.jtitle=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.au=Fung%2C+Hin+Tat+Jeffrey&rft.au=Lai%2C+Cing+Hon&rft.au=Wong%2C+Oi+Fung&rft.au=Lam%2C+Shing+Kit+Tommy&rft.date=2009-11-01&rft.issn=1556-3650&rft.eissn=1556-9519&rft.volume=47&rft.issue=9&rft.spage=902&rft.epage=903&rft_id=info:doi/10.3109%2F15563650903313541&rft.externalDBID=n%2Fa&rft.externalDocID=10_3109_15563650903313541
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1556-3650&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1556-3650&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1556-3650&client=summon