Hemolytic anemia after zopiclone overdose

Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. Case. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, rais...

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Published inClinical toxicology (Philadelphia, Pa.) Vol. 47; no. 9; pp. 902 - 903
Main Authors Fung, Hin Tat Jeffrey, Lai, Cing Hon, Wong, Oi Fung, Lam, Shing Kit Tommy, Lam, Ka Keung
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.11.2009
Taylor & Francis
Subjects
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - physiopathology
Azabicyclo Compounds - poisoning
Drug Overdose
Female
Follow-Up Studies
Hemolysis
Humans
Hypnotics and Sedatives - poisoning
Methemoglobinemia
Middle Aged
Oxidative Stress - drug effects
Piperazines - poisoning
Zopiclone
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Summary:Introduction. Zopiclone is associated with methemoglobinemia. We report a case of zopiclone overdose manifested with another hematological complication, hemolysis. Case. A 46-year-old woman overdosed with 50-100 tablets of 7.5 mg zopiclone. Oxidative hemolysis was evident by anemia, bite cells, raised unconjugated bilirubin and lactate dehydrogenase, lowered haptoglobin, and reticulocytosis. Discussion. In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.
ISSN:1556-3650
1556-9519
DOI:10.3109/15563650903313541