Polysaccharide-based superhydrophilic coatings with antibacterial and anti-inflammatory agent-delivering capabilities for ophthalmic applications

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 68; pp. 229 - 237
• Main Authors: Park, Sohyeon, Park, Joohee, Heo, Jiwoong, Lee, Sang-Eun, Shin, Jong-Wook, Chang, Minwook, Hong, Jinkee
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.12.2018; 한국공업화학회
• Subjects: Anti-inflammatory; Antibacterial coating; Layer by layer assembly; Ophthalmic silicone; Superhydrophilic nanofilm; 화학공학; Ophthalmic silicone; CHI; EDC; AFM; C(CMC/CHI)10 film; FT-IR; Superhydrophilic nanofilm; LPS; HNECs; LbL; CMC; NHS; FE-SEM; Layer by layer assembly; Antibacterial coating; Anti-inflammatory; Non_C(CMC/CHI)10 film; bPEI; ELISA
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2018.07.049

[Display omitted] Medical silicone tubes are generally used as implants for the treatment of nasolacrimal duct stenosis. However, side effects such as allergic reactions and bacterial infections have been reported following the silicone tube insertion, which cause surgical failure. These drawbacks can be overcome by modifying the silicone tube surface using a functional coating. Here, we report a biocompatible and superhydrophilic surface coating based on a polysaccharide multilayer nanofilm, which can load and release antibacterial and anti-inflammatory agents. The nanofilm is composed of carboxymethylcellulose (CMC) and chitosan (CHI), and fabricated by layer-by-layer (LbL) assembly. The LbL-assembled CMC/CHI multilayer films exhibited superhydrophilic properties, owing to the rough and porous structure obtained by a crosslinking process. The surface coated with the superhydrophilic CMC/CHI multilayer film initially exhibited antibacterial activity by preventing the adhesion of bacteria, followed by further enhanced antibacterial effects upon releasing the loaded antibacterial agent. In addition, inflammatory cytokine assays demonstrated the ability of the coating to deliver anti-inflammatory agents. The versatile nanocoating endows the surface with anti-adhesion and drug-delivery capabilities, with potential applications in the biomedical field. Therefore, we attempted to coat the nanofilm on the surface of an ophthalmic silicone tube to produce a multifunctional tube suitable for patient-specific treatment.