Human hair keratin-based hydrogels as dynamic matrices for facilitating wound healing

Recently, human hair-derived keratin protein has been recognized as biomaterial with high potential due to its excellent bioactivity and biocompatibility. Here, we designed human hair-derived keratin-based in situ cross-linkable hydrogels that can serve as a dynamic matrix for the enhanced wound hea...

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Published inJournal of industrial and engineering chemistry (Seoul, Korea) Vol. 73; pp. 142 - 151
Main Authors Kim, So Yeon, Park, Bong Joo, Lee, Yunki, Park, Na Jeong, Park, Kyung Min, Hwang, Yu-Shik, Park, Ki Dong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 25.05.2019
한국공업화학회
Subjects
Epithelial-Mesenchyme Transition
Hair keratin
Keratinocyte
Migration
Polymeric hydrogels
Wound healing
화학공학
Polymeric hydrogels
Keratinocyte
Wound healing
Epithelial-Mesenchyme Transition
Migration
Hair keratin
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Summary:Recently, human hair-derived keratin protein has been recognized as biomaterial with high potential due to its excellent bioactivity and biocompatibility. Here, we designed human hair-derived keratin-based in situ cross-linkable hydrogels that can serve as a dynamic matrix for the enhanced wound healing. We demonstrated that our developed the keratin-based hydrogels accelerated re-epithelization and wound healing process in a full-thickness animal. Also, we investigated the molecular mechanism underlying the enhanced wound healing. In conclusion, our study proposes that human hair-derived keratin-based hydrogels with excellent bioactivity have great potential for use as a wound healing material, along with its other biomedical applications.
ISSN:1226-086X
1876-794X
DOI:10.1016/j.jiec.2019.01.017