Correlation between expression of biological markers and [F]fluorodeoxyglucose uptake in endometrial cancer

• Published in: Oncology research and treatment Vol. 37; no. 1-2; p. 30
• Main Authors: Jo, Moo-Sung, Choi, Ook-Hwan, Suh, Dong-Soo, Yun, Man-Soo, Kim, Seong-Jang, Kim, Gi-Hyung, Jeon, Han-Na
• Format: Journal Article
• Language: English
• Published: Netherlands 2014
• Subjects: Adult; Aged; Biomarkers, Tumor - metabolism; Endometrial Neoplasms - diagnostic imaging; Endometrial Neoplasms - metabolism; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Humans; Middle Aged; Neoplasm Proteins - metabolism; Positron-Emission Tomography - methods; Radiopharmaceuticals - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic
• ISSN: 2296-5262
• DOI: 10.1159/000358163

Positron emission tomography/computer tomography (PET/CT) utilizing [(18)F]fluorodeoxyglucose ((18)F-FDG) has been recommended for the diagnosis, staging, therapy monitoring, prediction of prognosis, and detection of recurrence in endometrial cancer. We aimed to define the correlations of biological markers with (18)F-FDG uptake in endometrial cancer. 29 patients (55 ± 8.93 years) with endometrial cancer were included in this study. All patients underwent hysterectomy and bilateral salpingo-oophorectomy with or without para-aortic lymphadenectomy at the department of Obstetrics and Gynecology of Pusan National University Hospital. Immunohistochemical studies were performed for glucose transporter 1 (GLUT-1), hexokinase II (HK-II), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF) and carbonic anhydrase IX (CA-IX). There were positive correlations between FDG uptake and GLUT-1 (r = 0.375, p = 0.0452), and HK-II (r = 0.537, p = 0.0027). However, HIF-1α (r = 0.153, p = 0.4283), VEGF (r = -0,101, p = 0.6032) and CA-IX (r = 0.240, p = 0.2105) were not significantly associated with FDG uptake. No significant correlations were found among the expression levels of biological markers. FDG uptake in endometrial cancer was significantly associated with GLUT-1 and HK-II, while HIF-1α, VEGF and CA-IX were not associated with FDG uptake. No significant correlations were found among the expression levels of biological markers.