Lack of correlation between the location of choroidal melanoma and ultraviolet-radiation dose distribution

Ocular melanomas arise from the choroid. The results of our study of a total of 92 ocular melanomas would indicate that there is no preferential location for tumors on the eye. We estimated the ultraviolet (UV) radiation dose distribution using data available in the literature. We then compared tumo...

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Bibliographic Details
Published inRadiation research Vol. 147; no. 4; p. 451
Main Authors Schwartz, L H, Ferrand, R, Boelle, P Y, Maylin, C, D'Hermies, F, Virmont, J
Format Journal Article
LanguageEnglish
Published United States 01.04.1997
Subjects
Choroid Neoplasms - epidemiology
Choroid Neoplasms - pathology
Cornea - physiology
Dose-Response Relationship, Radiation
Humans
Lens, Crystalline - physiology
Melanoma - epidemiology
Melanoma - pathology
Models, Theoretical
Retina - radiation effects
Sunlight
Ultraviolet Rays
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Summary:Ocular melanomas arise from the choroid. The results of our study of a total of 92 ocular melanomas would indicate that there is no preferential location for tumors on the eye. We estimated the ultraviolet (UV) radiation dose distribution using data available in the literature. We then compared tumor location and UV-radiation dose distribution. UVC and UVB do not reach the choroid, and UVA is filtered by the cornea and the lens. Only a small percentage of the incoming rays reach the posterior and inferior part of the retina, but none reach the superior and anterior part of the eye. We concluded that it is therefore very unlikely that UV-radiation exposure is responsible for choroidal melanoma.
ISSN:0033-7587
DOI:10.2307/3579502