Generation of multifunctional encoded particles using a tetrapod microneedle injector

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 74; pp. 164 - 171
• Main Authors: Kang, Sung-Min, Rethinasabapathy, Muruganantham, Lee, Go-Woon, Kwak, Cheol Hwan, Park, Bumjun, Kim, Woo-Sik, Huh, Yun Suk
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.06.2019; 한국공업화학회
• Subjects: Alginate particle; Biomaterials; Custom-built; Encoding; Multifunctional; 화학공학; Custom-built; Encoding; Multifunctional; Alginate particle; Biomaterials
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2019.02.023

[Display omitted] •Multifunction encoded particles were successfully generated by using a tetrapod-like needle injector.•The particles were simply generated by the balance between gravity and surface tension.•Various functions can be encoded into single particles using the custom-built injector in one simple operation.•Tri-function encoded particles exhibited cesium adsorption, drug releasing, and magnetic actuation, simultaneously. Here we describe a tetrapod microneedle injector that produces multifunction encoded particles. The custom-built tetrapod-like needle injector consists of spatially oriented microneedles operated by micropump using programmed on and off sequences. For the purpose of this study to achieve various functions from one particle, each constituent contained in a multifunction encoded particle confirms the cesium adsorption of PB, the drug release behavior of DTPA, and rapid mixing of immiscible liquids due to magnetic actuation. We believe that the multi-functionalized particles may have synergistic multifunctional properties and push the boundaries of advanced biomaterials in biomedical engineering.