Ready and selective access to 2-arylquinazolines from α-amino acids via a new solvent-free domino transformation under synergistic nano Fe-Mo-Se catalyst

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 92; pp. 96 - 100
• Main Authors: Nguyen, Khang X., Pham, Phuc H., Nguyen, An C.D., Nguyen, Chuc T., Nguyen, Tung T., Tran, Phong D., Phan, Nam T.S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.12.2020; 한국공업화학회
• Subjects: Aminoacids; Molybdenum; Nano catalysis; Quinazolines; Selenide; Synergistic; 화학공학; Synergistic; Aminoacids; Selenide; Quinazolines; Nano catalysis; Molybdenum
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2020.08.027

[Display omitted] A Fe-Mo-Se nanopowder, synthesized by a solvothermal protocol, was utilized as a heterogeneous catalyst for the synthesis of 2-arylquinazolines from DL-α-phenylglycine-based α-amino acids and 2-nitrobenzyl alcohols via domino transformations. High yields and selectivity were achieved under solvent-free conditions. The Fe-Mo-Se catalyst offered considerably higher activity than numerous homogeneous and heterogeneous catalysts. To our best knowledge, this domino reaction is new, and the utilization of iron-molybdenum selenide catalyst in the synthesis of quinazolines was not previously reported. •Fe-Mo-Se nanopowder was utilized as a heterogeneous catalyst for a new synthesis of 2-arylquinazolines.•DL-α-phenylglycine-based α-amino acids were used as starting materials.•This domino reaction is new.•The catalyst was reusable.