Potassium Channels in Cancer

Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, mal...

Full description

Saved in:
Bibliographic Details
Published inHandbook of experimental pharmacology
Main Authors Ganser, Katrin, Klumpp, Lukas, Bischof, Helmut, Lukowski, Robert, Eckert, Franziska, Huber, Stephan M
Format Journal Article
LanguageEnglish
Published Germany 01.01.2021
Subjects
Chemotherapy
Tumour hypoxia
Oncochannels
Oncoimmunology
Metabolic reprogramming
Metastasis
Radiation therapy
Cancer stem cells
Tumour biology
Online AccessGet more information

Cover

More Information
Summary:Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These alterations have been identified as crucial elements of the tumourigenic reprogramming of cells. Potassium channels may contribute to cancer initiation, malignant progression and therapy resistance of tumour cells. The book chapter focusses on (oncogenic) potassium channels frequently upregulated in different tumour entities, upstream and downstream signalling of these channels, their contribution to the maintenance of cancer stemness and the formation of an immunosuppressive tumour microenvironment. In addition, their role in adaptation to tumour hypoxia, metabolic reprogramming, as well as tumour spreading and metastasis is discussed. Finally, we discuss how (oncogenic) potassium channels may confer treatment resistance of tumours against radiation and chemotherapy and thus might be harnessed for new therapy strategies, for instance, by repurposing approved drugs known to target potassium channels.
ISSN:0171-2004
DOI:10.1007/164_2021_465