The Prognostic Value of Soluble ST2 in Maintenance Hemodialysis Patients: A Meta-Analysis

• Published in: Blood purification Vol. 49; no. 1-2; pp. 114 - 120
• Main Authors: Wang, Shuang, Wei, Fang, Chen, Haiyan, Wang, Zhe, Zhang, Ruining, Jiang, Aili
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 2020
• Subjects: Hemodialysis – Meta-Analysis; Soluble ST2, sST2; Mortality; Kidney dialysis; Meta-analysis
• ISSN: 0253-5068; 1421-9735
• DOI: 10.1159/000503601

Background: Much controversy remains in the literature with respect to whether soluble suppression of tumorigenicity 2 (sST2) can serve to predict all-cause death in patients undergoing maintenance hemodialysis (MHD). This meta-analysis therefore sought to analyze extant datasets exploring the association between these 2 variables in MHD patients in order to draw relevant conclusions. Methods: Articles published through December 2018 in PubMed and Embase were independently reviewed by 2 authors to identify relevant articles, and STATA 12.0 was used for statistical analyses of relevant results and study parameters. Results: In total, we identified 4 relevant studies that were incorporated into this meta-analysis. These studies included a total of 1,924 participants (60% male, mean follow-up 911 days). The combined study results suggested that increased levels of sST2 were significantly linked to a 2.23 fold rise in all-cause mortality (hazard ratio [HR] 2.23, 95% CI 1.81–2.75). Subgroup analyses confirmed that this same association was true in patients undergoing hemodialysis (HR 2.17, 95% CI 1.74–2.71), which indicated that the increased levels of sST2 were significantly linked to a 2.17 fold rise in all-cause mortality. Conclusions: This analysis suggests that there is a significant link between elevated levels of sST2 and death in patients undergoing MHD. Further large-scale trials, however, will be needed to fully validate these findings and their clinical relevance.