Tetrakis(trimethylsilyl) Ethenylidenebisphosphonate: A Mild and Useful Reagent for the Synthesis of Substituted 2-Aminoethylidene-1,1-bisphosphonic Acids

Tetrakis(trimethylsilyl) ethenylidenebisphosphonate is proposed as a substrate in the preparations of N-substituted 2-aminoethylidene-1,1-bisphosphonic acids. The method provides an extremely mild protocol for the synthesis of these compounds and is compatible with a wide range of functional groups.

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Bibliographic Details
Published inPhosphorus, sulfur, and silicon and the related elements Vol. 186; no. 4; pp. 799 - 801
Main Authors Shevchuk, Michael V., Romanenko, Vadim D., Kukhar, Valery P.
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Group 31.03.2011
Taylor & Francis Ltd
Subjects
Acids
Aminobisphosphonic acids
Michael addition
tetrakis(trimethylsilyl) ethenylidenebisphosphonate
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Summary:Tetrakis(trimethylsilyl) ethenylidenebisphosphonate is proposed as a substrate in the preparations of N-substituted 2-aminoethylidene-1,1-bisphosphonic acids. The method provides an extremely mild protocol for the synthesis of these compounds and is compatible with a wide range of functional groups.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2010.500640