Regression of Experimentally Induced Endometriosis with a New Selective Cyclooxygenase-2 Enzyme Inhibitor

• Published in: Gynecologic and obstetric investigation Vol. 77; no. 1; pp. 35 - 39
• Main Authors: Kilico, Ismail, Kokcu, Arif, Kefeli, Mehmet, Kandemir, Bedri
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2014
• Subjects: Animals; Cyclooxygenase 2 Inhibitors - pharmacology; Disease Models, Animal; Endometriosis; Endometriosis - drug therapy; Endometriosis - enzymology; Endometriosis - pathology; Female; Ketoprofen - analogs & derivatives; Ketoprofen - pharmacology; Killer Cells, Natural - pathology; Original Article; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Tromethamine - pharmacology; Enzyme inhibitor; Endometriosis; Cyclooxygenase-2; Dexketoprofen trometamol
• ISSN: 0378-7346; 1423-002X
• DOI: 10.1159/000356686

Background: Cyclooxygenase-2 (COX-2) levels increase in women with endometriosis. COX-2, via increasing prostaglandin E 2 , contributes to an increase in vascular endothelial growth factor. In this way, COX-2 may contribute to the progression and continuity of endometriosis. We investigated the effect of dexketoprofen trometamol, a new selective COX-2 enzyme inhibitor, on experimentally induced endometriotic cysts. Methods: Experimental endometriotic cysts were created in 60 adult female Wistar albino rats. The rats were randomized to 2 equal groups, a control (group Con) and a dexketoprofen (group Dex) group. Six weeks later, cyst volumes were measured as in vivo (volume 1). Following volume 1 measurement, for 4 weeks group Con received 0.1 ml distilled water; group Dex received 0.375 mg dexketoprofen trometamol/0.1 ml distilled water, intramuscularly, twice a day. At the end of administration, the cyst volumes were remeasured (volume 2), and the cysts totally excised and weighed. Glandular (GT) and stromal tissues (ST) and natural killer (NK) cell contents in the cyst wall were scored. Results: NK cell content and volume 1 were not different between the 2 groups. Volume 2, cyst weight, and GT and ST contents in group Dex were significantly lower than those in group Con. Conclusion: Dexketoprofen trometamol significantly reduced the development of experimentally induced endometriotic cysts both macroscopically and microscopically.